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Tytuł pozycji:

Independent risk factors for axillary lymph node metastasis in breast cancer patients with one or two positive sentinel lymph nodes.

Tytuł:
Independent risk factors for axillary lymph node metastasis in breast cancer patients with one or two positive sentinel lymph nodes.
Autorzy:
Zhang, Wei
Xu, Jing
Wang, Ke
Tang, Xiao-Jiang
Liang, Hua
He, Jian-Jun
Temat:
METASTATIC breast cancer
SENTINEL lymph nodes
LYMPH nodes
CANCER patients
AXILLARY lymph node dissection
LYMPH node cancer
LYMPHATIC metastasis
Źródło:
BMC Women's Health; 7/9/2020, Vol. 20 Issue 1, p1-9, 9p, 3 Charts
Czasopismo naukowe
Background: The benefit of axillary lymph node dissection (ALND) in breast cancer patients with one or two positive sentinel lymph nodes (SLNs) remains inconclusive. The purpose of this study was to identify risk factors independently associated with axillary lymph node (ALN) metastasis.Methods: We retrospectively analyzed data from 389 Chinese breast cancer patients with one or two positive SLNs who underwent ALND. Univariate and multivariate logistic regression analyses were performed to identify ALN metastasis-associated risk factors.Results: Among the 389 patients, 174 (44.7%) had ALN metastasis, while 215 (55.3%) showed no evidence of ALN metastasis. Univariate analysis revealed significant differences in age (< 60 or ≥ 60 years), human epidermal growth factor receptor-2 (Her-2) status, and the ratio of positive to total SLNs between the ALN metastasis and non-metastasis groups (P < 0.05). The multivariate analysis indicated that age, the ratio of positive to total SLNs, and occupations were significantly different between the two groups. Lastly, younger age (< 60 years), a higher ratio of positive to total SLNs, and manual labor jobs were independently associated with ALN metastasis (P < 0.05).Conclusions: The risk of ALN metastasis in breast cancer patients with one or two positive SLNs can be further increased by younger age, manual labor jobs, and a high ratio of positive to total SLNs. Our findings may also aid in identifying which patients with one or two positive SLNs may not require ALND. [ABSTRACT FROM AUTHOR]
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