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Tytuł:
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Neuropsychological, clinical and environmental predictors of severe mental disorders in offspring of patients with schizophrenia.
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Autorzy:
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Sánchez-Gutiérrez, Teresa
Rodríguez-Toscano, Elisa
Llorente, Cloe
de la Serna, Elena
Moreno, Carmen
Sugranyes, Gisela
Romero, Soledad
Calvo, Ana
Baeza, Immaculada
Sánchez-Gistau, Vanessa
Espliego, Ana
Castro-Fornieles, Josefina
Moreno, Dolores
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Temat:
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MENTAL illness
VERBAL memory
VERBAL learning
PEOPLE with schizophrenia
VISUAL memory
SYMPTOMS
22Q11 deletion syndrome
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Źródło:
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European Archives of Psychiatry & Clinical Neuroscience; Sep2020, Vol. 270 Issue 6, p739-748, 10p, 3 Charts
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Offspring of individuals with schizophrenia (SZCOff) are at an increased risk for this disorder. Neuropsychological decline is a core feature of the disorder and researchers have reported increasing impairments in cognition during the prodromal phase in high-risk adolescents. Additionally, factors like the presence of prodromal symptoms or specific behavioral patterns could predict, together with neurocognitive functioning, the risk of conversion to severe mental disorders in SCZOff. This study aims to compare the neuropsychological functioning of a sample of 41 SCZOff children and adolescents and 105 community control offspring (CCOff) and to develop a prediction model to examine whether neuropsychological functioning, clinical and behavioral factors predict subsequent risk of severe mental disorders. We collected demographic, clinical and neuropsychological data. We found significant differences between groups in working memory, speed of processing, verbal memory and learning, visual memory and intelligence quotient (IQ). The socioeconomic status, verbal memory, working memory and positive prodromal symptoms predicted a significant proportion of the dependent variable variance. In conclusion, SCZOff showed neurocognitive impairments in several neuropsychological domains compared to CCOff. Neuropsychological functioning, environmental factors and positive prodromal symptoms could predict the risk of onset of severe mental disorders in SCZOff. [ABSTRACT FROM AUTHOR]
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