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Tytuł pozycji:

Viremia copy-years and risk of estimated glomerular filtration rate reduction in adults living with perinatal HIV infection.

Tytuł :
Viremia copy-years and risk of estimated glomerular filtration rate reduction in adults living with perinatal HIV infection.
Autorzy :
Sarteschi, Giovanni
Di Biagio, Antonio
Focà, Emanuele
Taramasso, Lucia
Bovis, Francesca
Celotti, Anna
Mirabella, Michele
Magnasco, Laura
Mora, Sara
Giacomini, Mauro
Bassetti, Matteo
Pokaż więcej
Temat :
VERTICAL transmission (Communicable diseases)
HIV infections
GLOMERULAR filtration rate
NON-nucleoside reverse transcriptase inhibitors
VIREMIA
Źródło :
PLoS ONE; 10/15/2020, Vol. 15 Issue 10, p1-8, 8p
Czasopismo naukowe
Among people with perinatal HIV infection (PHIV), non-communicable diseases, such as chronic kidney disease, are increasing. Both HIV replication and antiretroviral therapy are recognised causes of renal impairment. Objective of the study is to describe the impact of viremia copy-years (VCY) and antiretroviral therapy on trend of estimated glomerular filtration rate (eGFR) in a cohort of adults with perinatal HIV infection. We conducted a multicentre observational study in sixty adults living with PHIV across a 9-year period, from January 2010 to December 2018. The mean values of eGFR were analysed at the first (T0) and last year of observation (T1). VCY was defined as the area under HIV-RNA curve during the study period. We analysed data according to antiretroviral therapy: tenofovir disoproxil (TDF), non-nucleoside reverse transcriptase inhibitors (NNRTI), boosted protease inhibitors (PI/b), integrase inhibitors (INI). We observed a mean overall eGFR reduction from 126.6 mL/min (95%CI: 119.6–133.5) to 105.0 mL/min (95%CI: 99.55–110.6) (p<0.001). Older age, higher baseline eGFR, higher VCY and longer exposure to INI treatment were associated with eGFR reduction at univariate analysis. In the multivariate model, older age (p = 0.039), baseline eGFR (p<0.001) and VCY (p = 0.069), were retained. We also observed a longer exposure to PI/b and INI in patients with lower control on HIV-RNA, expressed as VCY>2 log10. Our study outlines a progressive eGFR reduction in young adults with PHIV, related to the lower control on HIV-RNA VCY and related to aging. [ABSTRACT FROM AUTHOR]
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