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Tytuł pozycji:

Laboratory Tests and Outcome for Patients with Coronavirus Disease 2019: A Systematic Review and Meta-Analysis.

Tytuł :
Laboratory Tests and Outcome for Patients with Coronavirus Disease 2019: A Systematic Review and Meta-Analysis.
Autorzy :
Alnor, Anne
Sandberg, Maria B.
Gils, Charlotte
Vinholt, Pernille J.
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Temat :
SARS-CoV-2
COVID-19
BIOMARKERS
LEUKOCYTE count
C-reactive protein
LACTATE dehydrogenase
Źródło :
Journal of Applied Laboratory Medicine; Sep2020, Vol. 5 Issue 5, p1038-1049, 12p
Czasopismo naukowe
Background: Severe acute respiratory syndrome coronavirus 2 causes coronavirus disease 2019 (COVID-19) and poses substantial challenges for healthcare systems. With a vastly expanding number of publications on COVID-19, clinicians need evidence synthesis to produce guidance for handling patients with COVID-19. In this systematic review and meta-analysis, we examine which routine laboratory tests are associated with severe COVID-19 disease. Content: PubMed (Medline), Scopus, and Web of Science were searched until March 22, 2020, for studies on COVID-19. Eligible studies were original articles reporting on laboratory tests and outcome of patients with COVID-19. Data were synthesized, and we conducted random-effects meta-analysis, and determined mean difference (MD) and standard mean difference at the biomarker level for disease severity. Risk of bias and applicability concerns were evaluated using the Quality Assessment of Diagnostic Accuracy Studies-2. Summary: 45 studies were included, of which 21 publications were used for the meta-analysis. Studies were heterogeneous but had low risk of bias and applicability concern in terms of patient selection and reference standard. Severe disease was associated with higher white blood cell count (MD, 1.28 x 109 /L), neutrophil count (MD, 1.49 x 109 /L), C-reactive protein (MD, 49.2mg/L), lactate dehydrogenase (MD, 196U/L), D-dimer (standardized MD, 0.58), and aspartate aminotransferase (MD, 8.5U/L); all p<0.001. Furthermore, low lymphocyte count (MD -0.32 x 109 /L), platelet count (MD -22.4 x 109 /L), and hemoglobin (MD, -4.1 g/L); all p<0.001 were also associated with severe disease. In conclusion, several routine laboratory tests are associated with disease severity in COVID-19. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Applied Laboratory Medicine is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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