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Tytuł:
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Toll-Like Receptor 2 Promoter -196 to -174 Deletion Affects CD4 Levels Along Human Immunodeficiency Virus Infection Progression.
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Autorzy:
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Laplana, Marina
Bravo, Maria Jose
Fernández-Fuertes, Marta
Ruiz-Garcia, Celia
Alarcón-Martin, Emilio
Colmenero, Juan de Dios
Caruz, Antonio
Fibla, Joan
Real, Luis Miguel
Royo, Jose Luis
Laplana, M
Bravo, M J
Fernández-Fuertes, M
Ruiz-Garcia, C
Alarcón-Martin, E
Colmenero, J D
Caruz, A
Fibla, J
Real, L M
Royo, J L
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Temat:
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HIV infections
HIV
TOLL-like receptors
DISEASE progression
RESEARCH
RESEARCH methodology
CELL receptors
GENETIC polymorphisms
PROGNOSIS
MEDICAL cooperation
EVALUATION research
COMPARATIVE studies
CD4 lymphocyte count
GENES
SURVIVAL analysis (Biometry)
LONGITUDINAL method
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Źródło:
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Journal of Infectious Diseases; 12/15/2020, Vol. 222 Issue 12, p2007-2011, 5p
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Toll-like receptor 2 (TLR2) plays a key role in innate immune response recognizing molecular patterns expressed by pathogens. rs111200466 is a TLR2 promoter insertion/deletion polymorphism with contradictory data about its role in human immunodeficiency virus type 1 (HIV-1) infection. We analyzed rs111200466 in HIV-1 disease progression and showed a correlation with a faster progression to the CD4+ < 200 cells/μL outcome for deletion allele carriers (Cox regression analysis: hazard ratio, 2.4 [95% confidence interval, 1.4-4]; P = .001). When naive patients with CD4+ < 200 cells/μL started antiretroviral treatment, rs111200466-deletion carriers showed a trend toward a slower, recovery rate (time required to reach CD4+ > 350 cells/μL; Cox P = .36). Our data suggest rs111200466 as a prognosis factor for HIV-1 disease progression. [ABSTRACT FROM AUTHOR]
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