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Tytuł:
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Anakinra usage in febrile infection related epilepsy syndrome: an international cohort.
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Autorzy:
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Lai, Yi‐Chen
Muscal, Eyal
Wells, Elizabeth
Shukla, Nikita
Eschbach, Krista
Hyeong Lee, Ki
Kaliakatsos, Marios
Desai, Nevedita
Wickström, Ronny
Viri, Maurizio
Freri, Elena
Granata, Tiziana
Nangia, Srishti
Dilena, Robertino
Brunklaus, Andreas
Wainwright, Mark S.
Gorman, Mark P.
Stredny, Coral M.
Asiri, Abdurhman
Hundallah, Khalid
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Temat:
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NEUROLOGICAL disorders
INTERLEUKIN-1 receptors
ARTIFICIAL respiration
STATUS epilepticus
LENGTH of stay in hospitals
ANAKINRA
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Źródło:
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Annals of Clinical & Translational Neurology; Dec2020, Vol. 7 Issue 12, p2467-2474, 8p
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Febrile‐infection related epilepsy syndrome (FIRES) is a devastating neurological condition characterized by a febrile illness preceding new onset refractory status epilepticus (NORSE). Increasing evidence suggests innate immune dysfunction as a potential pathological mechanism. We report an international retrospective cohort of 25 children treated with anakinra, a recombinant interleukin‐1 receptor antagonist, as an immunomodulator for FIRES. Anakinra was potentially safe with only one child discontinuing therapy due to infection. Earlier anakinra initiation was associated with shorter duration of mechanical ventilation, ICU and hospital length of stay. Our retrospective data lay the groundwork for prospective consensus‐driven cohort studies of anakinra in FIRES. [ABSTRACT FROM AUTHOR]
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