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Tytuł pozycji:

Fast in vivo 23Na imaging and T2∗ mapping using accelerated 2D‐FID UTE magnetic resonance spectroscopic imaging at 3 T: Proof of concept and reliability study.

Tytuł :
Fast in vivo Na imaging and T2∗ mapping using accelerated 2D‐FID UTE magnetic resonance spectroscopic imaging at 3 T: Proof of concept and reliability study.
Autorzy :
Alhulail, Ahmad A.
Xia, Pingyu
Shen, Xin
Nichols, Miranda
Volety, Srijyotsna
Farley, Nicholas
Thomas, Micheal Albert
Nagel, Armin M.
Dydak, Ulrike
Emir, Uzay E.
Pokaż więcej
Temat :
MAGNETIC resonance imaging
CALF muscles
PROOF of concept
SKELETAL muscle
Źródło :
Magnetic Resonance in Medicine; Apr2021, Vol. 85 Issue 4, p1783-1794, 12p
Czasopismo naukowe
Purpose: To implement an accelerated MR‐acquisition method allowing to map T2∗ relaxation and absolute concentration of sodium within skeletal muscles at 3T. Methods: A fast‐UTE‐2D density‐weighted concentric‐ring‐trajectory 23Na‐MRSI technique was used to acquire 64 time points of FID with a spectral bandwidth of 312.5 Hz with an in‐plane resolution of 2.5 × 2.5 mm2 in ~15 min. The fast‐relaxing 23Na signal was localized with a single‐shot, inversion‐recovery‐based, non‐echo (SIRENE) outer volume suppression (OVS) method. The sequence was verified using simulation and phantom studies before implementing it in human calf muscles. To evaluate the 2D‐SIRENE‐MRSI (UTE = 0.55 ms) imaging performance, it was compared to a 3D‐MRI (UTE = 0.3 ms) sequence. Both data sets were acquired within 2 same‐day sessions to assess repeatability. The T2∗ values were fitted voxel‐by‐voxel using a biexponential model for the 2D‐MRSI data. Finally, intra‐subject coefficients of variation (CV) were estimated. Results: The MRSI‐FID data allowed us to map the fast and slow components of T2∗ in the calf muscles. The spatial distributions of 23Na concentration for both MRSI and 3D‐MRI acquisitions were significantly correlated (P <.001). The test–retest analysis rendered high repeatability for MRSI with a CV of 5%. The mean T2Fast∗ in muscles was 0.7 ± 0.1 ms (contribution fraction = 37%), whereas T2Slow∗ was 13.2 ± 0.2 ms (63%). The mean absolute muscle 23Na concentration calculated from the T2∗‐corrected data was 28.6 ± 3.3 mM. Conclusion: The proposed MRSI technique is a reliable technique to map sodium's absolute concentration and T2∗ within a clinically acceptable scan time at 3T. [ABSTRACT FROM AUTHOR]
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