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Tytuł:
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5-Aminolevulinic acid hydrochloride loaded microbubbles-mediated sonodynamic therapy in pancreatic cancer cells.
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Autorzy:
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Yang, Wei
Xu, Haitao
Liu, Qinghao
Liu, Chunxun
Hu, Jiahe
Liu, Ping
Fang, Tianyi
Bai, Yuxian
Zhu, Jiuxin
Xie, Rui
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Temat:
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PANCREATIC cancer
CANCER cells
MICROBUBBLES
REACTIVE oxygen species
CANCER treatment
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Źródło:
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Artificial Cells, Nanomedicine & Biotechnology; Dec2020, Vol. 48 Issue 1, p1178-1188, 11p
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5-Aminolevulinic acid hydrochloride (ALA)-mediated sonodynamic therapy (SDT) had anti-tumour effect on pancreatic cancer cells. Hence, ALA loaded lipid/poly(lactic-co-glycolic acid) (PLGA) microbubbles (MBs)-mediated SDT for pancreatic cancer has great potential. The average size of ALA-lipid MBs and ALA-PLGA MBs was about 3.0 µm. The two kinds of MBs had good biocompatibility to normal HPDE6-C7 cells and were not toxic to pancreatic cancer cells. Compared with ALA-induced SDT, a statistically significant decrease in cell viability was observed in ALA lipid/PLGA MBs combined with ultrasound groups in AsPC-1 and BxPC-3 cells (p <.05). Obvious effect on the apoptotic rate, apoptosis and pyroptosis morphology, enhanced reactive oxygen species was found in ALA-lipid/PLGA MBs mediated SDT in vitro. Through in vivo study, we found ALA-lipid/PLGA MBs-mediated SDT was a promise treatment for pancreatic cancer. [ABSTRACT FROM AUTHOR]
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