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Tytuł:
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Hypokalemia in Patients with COVID-19.
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Autorzy:
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Alfano, Gaetano
Ferrari, Annachiara
Fontana, Francesco
Perrone, Rossella
Mori, Giacomo
Ascione, Elisabetta
Magistroni, Riccardo
Venturi, Giulia
Pederzoli, Simone
Margiotta, Gianluca
Romeo, Marilina
Piccinini, Francesca
Franceschi, Giacomo
Volpi, Sara
Faltoni, Matteo
Ciusa, Giacomo
Bacca, Erica
Tutone, Marco
Raimondi, Alessandro
Menozzi, Marianna
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Temat:
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COVID-19
HYPOKALEMIA
WATER-electrolyte imbalances
PATIENTS' attitudes
HOSPITAL mortality
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Źródło:
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Clinical & Experimental Nephrology; Apr2021, Vol. 25 Issue 4, p401-409, 9p
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Terminy geograficzne:
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MODENA (Italy)
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Background: Patients with COVID-19 experience multiple clinical conditions that may cause electrolyte imbalances. Hypokalemia is a concerning electrolyte disorder closely associated with severe complications. This study aimed to estimate prevalence, risk factors and outcome of hypokalemia in a cohort of patients with confirmed COVID-19. Methods: A retrospective analysis was conducted on 290 non-ICU admitted patients with COVID-19 at the tertiary teaching hospital of Modena, Italy, from February 16 to April 14, 2020. Results: Hypokalemia was detected in 119 out of 290 patients (41%) during hospitalization. Mean serum potassium was 3.1 ± 0.1 meq/L. The majority of patients (90.7%) patients experienced only a mild decrease in serum potassium level (3–3.4 mEq/L). Hypokalemia was associated with hypocalcemia, which was detected in 50% of subjects. Urine potassium-to-creatinine ratio, measured in a small number of patients (n = 45; 36.1%), revealed an increase of urinary potassium excretion in most cases (95.5%). Risk factors for hypokalemia were female sex (odds ratio (OR) 2.44; 95% CI 1.36–4.37; P 0.003) and diuretic therapy (OR 1.94, 95% CI 1.08–3.48; P 0.027). Hypokalemia, adjusted for sex, age and SOFA score, was not associated with ICU transfer (OR 0.52; 95% CI 0.228–1.212; P = 0.131), in-hospital mortality (OR, 0.47; 95% CI 0.170–1.324; P = 0.154) and composite outcome of ICU transfer or in-hospital mortality (OR 0.48; 95% CI 0.222–1.047; P = 0.065) in our cohort of patients. Conclusions: Hypokalemia was a frequent disorder in subjects with COVID-19. Female sex and diuretic therapy were identified as risk factors for low serum potassium levels. Hypokalemia was unrelated to ICU transfer and death in this cohort of patients. [ABSTRACT FROM AUTHOR]
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