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Tytuł:
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The transplant cohort of the German center for infection research (DZIF Tx-Cohort): study design and baseline characteristics.
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Autorzy:
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Karch, André
Schindler, Daniela
Kühn-Steven, Andrea
Blaser, Rainer
Kuhn, Klaus A.
Sandmann, Lisa
Sommerer, Claudia
Guba, Markus
Heemann, Uwe
Strohäker, Jens
Glöckner, Stephan
Mikolajczyk, Rafael
Busch, Dirk H.
Schulz, Thomas F.
for the Transplant Cohort of the German Center for Infection Research (DZIF Transplant Cohort) Consortium
Lehmann, Andreas
Ganser, Arnold
Lange, Berit
Maecker-Kolhoff, Britta
Tönshoff, Burkhard
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Temat:
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STEM cell transplantation
TRANSPLANTATION of organs, tissues, etc.
RESEARCH institutes
EXPERIMENTAL design
STANDARD operating procedure
ARTIFICIAL pancreases
ARTIFICIAL hearts
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Źródło:
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European Journal of Epidemiology; Feb2021, Vol. 36 Issue 2, p233-241, 9p
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Infectious complications are the major cause of morbidity and mortality after solid organ and stem cell transplantation. To better understand host and environmental factors associated with an increased risk of infection as well as the effect of infections on function and survival of transplanted organs, we established the DZIF Transplant Cohort, a multicentre prospective cohort study within the organizational structure of the German Center for Infection Research. At time of transplantation, heart-, kidney-, lung-, liver-, pancreas- and hematopoetic stem cell- transplanted patients are enrolled into the study. Follow-up visits are scheduled at 3, 6, 9, 12 months after transplantation, and annually thereafter; extracurricular visits are conducted in case of infectious complications. Comprehensive standard operating procedures, web-based data collection and monitoring tools as well as a state of the art biobanking concept for blood, purified PBMCs, urine, and faeces samples ensure high quality of data and biosample collection. By collecting detailed information on immunosuppressive medication, infectious complications, type of infectious agent and therapy, as well as by providing corresponding biosamples, the cohort will establish the foundation for a broad spectrum of studies in the field of infectious diseases and transplant medicine. By January 2020, baseline data and biosamples of about 1400 patients have been collected. We plan to recruit 3500 patients by 2023, and continue follow-up visits and the documentation of infectious events at least until 2025. Information about the DZIF Transplant Cohort is available at https://www.dzif.de/en/working-group/transplant-cohort. [ABSTRACT FROM AUTHOR]
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