Subsequently, the children died due to treatment-related toxicities, including veno-occlusive disease (n=1) or metastatic haemorrhage (n=1) [ I time to reactions onset not stated i ]. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event In a retrospective study including 92 children, conducted between 2002 and 2015, two children [ I sexes and exact ages not stated i ] were described, who developed veno-occlusive disease (n=1) or metastatic haemorrhage (n=1) during treatment with carboplatin and etoposide for metastatic medulloblastoma. [Extracted from the article]
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