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Tytuł pozycji:

Transcriptome analysis of gravitational effects on mouse skeletal muscles under microgravity and artificial 1 g onboard environment.

Tytuł :
Transcriptome analysis of gravitational effects on mouse skeletal muscles under microgravity and artificial 1 g onboard environment.
Autorzy :
Okada, Risa
Fujita, Shin-ichiro
Suzuki, Riku
Hayashi, Takuto
Tsubouchi, Hirona
Kato, Chihiro
Sadaki, Shunya
Kanai, Maho
Fuseya, Sayaka
Inoue, Yuri
Jeon, Hyojung
Hamada, Michito
Kuno, Akihiro
Ishii, Akiko
Tamaoka, Akira
Tanihata, Jun
Ito, Naoki
Shiba, Dai
Shirakawa, Masaki
Muratani, Masafumi
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Temat :
TRANSCRIPTOMES
GRAVITATIONAL effects
SKELETAL muscle
REDUCED gravity environments
SPACE flight
Źródło :
Scientific Reports; 4/28/2021, Vol. 11 Issue 1, p1-15, 15p
Czasopismo naukowe
Spaceflight causes a decrease in skeletal muscle mass and strength. We set two murine experimental groups in orbit for 35 days aboard the International Space Station, under artificial earth-gravity (artificial 1 g; AG) and microgravity (μg; MG), to investigate whether artificial 1 g exposure prevents muscle atrophy at the molecular level. Our main findings indicated that AG onboard environment prevented changes under microgravity in soleus muscle not only in muscle mass and fiber type composition but also in the alteration of gene expression profiles. In particular, transcriptome analysis suggested that AG condition could prevent the alterations of some atrophy-related genes. We further screened novel candidate genes to reveal the muscle atrophy mechanism from these gene expression profiles. We suggest the potential role of Cacng1 in the atrophy of myotubes using in vitro and in vivo gene transductions. This critical project may accelerate the elucidation of muscle atrophy mechanisms. [ABSTRACT FROM AUTHOR]
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