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Tytuł:
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Botulinum toxin type-A preparations are not the same medications -- basic science (Part 1).
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Autorzy:
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Car, Halina
Bogucki, Andrzej
Bonikowski, Marcin
Dec-Ćwiek, Małgorzata
Drużdż, Artur
Koziorowski, Dariusz
Rudzińska-Bar, Monika
Sarzyńska-Długosz, Iwona
Sławek, Jarosław
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Temat:
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BACTERIAL toxins
BOTULINUM A toxins
MEDICAL practice
PHARMACOLOGY
THERAPEUTIC equivalency in drugs
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Źródło:
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Polish Journal of Neurology & Neurosurgery / Neurologia i Neurochirurgia Polska; 2021, Vol. 55 Issue 2, p133-140, 8p
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Botulinum neurotoxin type-A (BoNT/A) formulations are widely used in clinical practice. Although they share a common mechanism of action resulting in presynaptic block in acetylocholine release, their structure and pharmacological properties demonstrate some similarities and many differences. Bioequivalence has been discussed since the onset of the clinical use of BoNT/A. In this review, we provide an update on the studies and compare the molecular structure, mechanisms of action, diffusion and spread, as well as immunogenicity and dose equivalence of onabotulinumtoxinA, abobotulinumtoxinA and incobotulinumtoxinA. [ABSTRACT FROM AUTHOR]
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