Pokroky v léčbě autoimunitních neuropatií. (Czech)

Szczegóły
Abstrakt

Tytuł:: Pokroky v léčbě autoimunitních neuropatií. (Czech)
Autorzy:: Ehler, Edvard
Štětkářová, Ivana
Alternatywny tytuł:: Progress in therapy of autoimmune neuropathies. (English)
Źródło:: Neurologie Pro Praxi; Oct2021, Vol. 22 Issue 3, p201-205, 5p
Abstract (English):: Autoimmune neuropathies develope on the gound of immune reaction against own tissue. The tissue can be myelin sheath, proper axon or vascular supply - vasulitis. In only few neuropathies the antibody is known (e.g. GQ1b in Miller-Fisher syndroma) and in other neuropathies the autoantibodies are suspected or some other autoimmune reaction is considered. Corticosteroids are contraindicated. In chronic inflammatory polyneuropathy the treatment begins with induction therapy - intravenous application of immunoglobulins or oral medication with corticosteroids with the target dosis of 1-2 mg pro kilogram of body mass. In rare cases plasma exchange or immune adsorption are used. More frequently subcutaneous application of immunoglobulins comes to use. For chronic medication corticosteroids, immunoglobulins (intravenous or subcutanneous) and combined with immunosuprresives, because of corticoid - or immunoglobulin-sparing effects. In variants with IgG4 class antibodies a monoclonal antibody rituximab is effectively used. In the treatment of multifocal motor neuropathy are immunoglobulins (intravenous or subcutaneous) most frequently in use. Looking to substantial adverse reaction is cyclophosphamid used only for a short period. [ABSTRACT FROM AUTHOR]
: Czasopismo naukowe

Copyright of Neurologie Pro Praxi is the property of SOLEN sro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Informacja