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Tytuł pozycji:

COVID-19 in B Cell-Depleted Patients After Rituximab: A Diagnostic and Therapeutic Challenge.

Tytuł:
COVID-19 in B Cell-Depleted Patients After Rituximab: A Diagnostic and Therapeutic Challenge.
Autorzy:
Furlan, Anna
Forner, Gabriella
Cipriani, Ludovica
Vian, Elisa
Rigoli, Roberto
Gherlinzoni, Filippo
Scotton, Piergiorgio
Temat:
COVID-19
THERAPEUTICS
B cell lymphoma
RITUXIMAB
MUSCULOSKELETAL system diseases
Źródło:
Frontiers in Immunology; 11/3/2021, Vol. 12, p1-10, 10p
Czasopismo naukowe
B cell-targeting strategies such as rituximab are widely used in B cell hematologic malignancies, rheumatologic and musculoskeletal diseases and a variety of autoimmune disorders. The purpose of this paper is to illustrate how exposure to anti-CD20 treatment profoundly affects B cell functions involved in anti-SARS-CoV-2 immunity and significantly impacts on the clinical and serological course of SARS-CoV-2 infection, long term immunity and vaccine responses. The data presented here suggest that the effects of B cell-depleting agents on adaptive immunity should be taken into account for the proper selection and interpretation of SARS-CoV-2 diagnostics and to guide appropriate therapeutic approaches and protective measures. Combination therapeutic strategies including immunotherapy in association with prolonged antiviral treatment may play a decisive role in the setting of B cell immune deficiencies. [ABSTRACT FROM AUTHOR]
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