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Tytuł pozycji:

Soluble Tac peptide is present in the urine of normal individuals and at elevated levels in patients with adult T cell leukaemia (ATL).

Tytuł :
Soluble Tac peptide is present in the urine of normal individuals and at elevated levels in patients with adult T cell leukaemia (ATL).
Autorzy :
Marcon, Luisa
Fritz, Mary E.
Kurman, Carole C.
Jensen, J. C.
Nelson, D. L.
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Temat :
T cells
LYMPHOKINES
URINE
INTERLEUKIN-2
LEUKEMIA
CANCER
Źródło :
Clinical & Experimental Immunology; Jul1988, Vol. 73 Issue 1, p29-33, 5p
Czasopismo naukowe
The T lymphocyte-derived lymphokine interleukin 2 and the cell-associated receptor for this molecule play major roles in the activation and regulation of the human immune response. An enzyme-linked immunosorbent assay has been developed to measure quantitatively a soluble form of one component of the human interleukin 2 receptor, namely the Tac peptide. In the present studies, soluble Tac peptide was measured in the urine of normal individuals (mean =92 U/ml), a level not significantly different (0.01 < P<0.05) from the corresponding serum concentrations (mean= 175). The urinary Tac peptide had a molecular weight of 40-45 kD by sodium dodecyl sulphatepolyacrylamide gel electrophoresis analysis and specifically bound interleukin 2. Elevated levels of urinary Tac peptide were found in four patients with adult T cell leukaemia who also had elevated serum levels of Tac peptide. Thus, urine may represent a valuable source of lymphokine-binding proteins that may serve as important markers of immunological activation. [ABSTRACT FROM AUTHOR]
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