The Action of Secretin, Trypsin and Histamine on the Motility of Canine Intestinal Villi.

Gradually increasing doses of secretin, trypsin and histamine were injected into the artery of the first jejunal loop of groups of dogs to determine the number of villous contractions and to study the early capillary effects as well as that upon the jejunal mucous membrane. Secretin significantly increased and trypsin reduced the number of intestinal villous contractions. Histamine increased it when given in a dose lower than 1 µg. and reduced it when a 1 µg. dose was administered, Larger doses of secretin, or trypsin, or histamine elicited spastic contractions of the intestinal villi. In the villi and in the intestinal mucous membrane these agents gave rise to ischemia, dilated the blood capillaries, caused stasis in them and produced pericapillary bleeding. Both in manifestation and in extent this early vascular reaction greatly resembled the impairment of the microcircolation in the mucous membrane seen in experimentally-induced pancreatitis. It is suggested that secretin, trypsin and histamine may inhibit the motor function of the stomach and jejunum in acute pancreatitis. [ABSTRACT FROM AUTHOR]
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