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Tytuł pozycji:

Lack of effect of genetic polymorphisms of SLCO1B1 on the lipid-lowering response to pitavastatin in Chinese patients.

Tytuł :
Lack of effect of genetic polymorphisms of SLCO1B1 on the lipid-lowering response to pitavastatin in Chinese patients.
Autorzy :
Guo-ping YANG
Hong YUAN
Bin TANG
Wei ZHANG
Lian-sheng WANG
Zhi-jun HUANG
Dong-sheng OU-YANG
Gui-xiang ZHANG
Hong-hao ZHOU
Pokaż więcej
Temat :
GENETIC polymorphisms
HYPERLIPIDEMIA
ANTILIPEMIC agents
CHINESE people
CHOLESTEROL
TRIGLYCERIDES
HIGH density lipoproteins
Źródło :
Acta Pharmacologica Sinica; Mar2010, Vol. 31 Issue 3, p382-386, 5p, 3 Charts
Czasopismo naukowe
AbstractAim:To investigate the SLCO1B1 388A>G and 521T>C polymorphisms in hyperlipidemia patients and evaluate the effect of the two polymorphisms on the lipid-lowering efficacy of pitavastatin.Methods:The functional polymorphisms of SLCO1B1 (388A>G and 521T>C) were genotyped in 140 Chinese patients with essential hyperlipidemia using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and one-step tetra-primers ARMS-PCR. Eighty-five patients were enrolled in the clinical trial and given 2 mg of pitavastatin daily for 8 weeks. Total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) serum levels were measured at baseline, after 4 weeks and after 8 weeks of treatment.Results:The allele frequencies of SLCO1B1 388A>G and 521T>C in essential hyperlipidemia patients were 71.1% and 11.1%, respectively. The 4- and 8-week treatment with pitavastatin significantly reduced TC, TG, and LDL levels, but there was no statistical difference among patients with wild type, SLCO1B1 388A>G or SLCO1B1 521T>C in the lipid-lowering efficacy of pitavastatin.Conclusion:The present study found that the allele frequencies of SLCO1B1 388A>G and 521T>C in Chinese patients with essential hyperlipidemia are comparable to those in healthy Chinese population. SLCO1B1 388A>G and 521T>C do not affect the lipid-lowering efficacy of pitavastatin. [ABSTRACT FROM AUTHOR]
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