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Tytuł:
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Investigation of a plasmid containing a novel immunotoxin VEGF165-PE38 gene for antiangiogenic therapy in a malignant glioma model.
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Autorzy:
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Hu, Chang-chen
Ji, Hong-ming
Chen, Sheng-li
Zhang, Han-wei
Wang, Bin-quan
Zhou, Li-yuan
Zhang, Zi-ping
Sun, Xin-lin
Chen, Zhen-zhou
Cai, Ying-qian
Qin, Ling-sha
Lu, Li
Jiang, Xiao-dan
Xu, Ru-xiang
Ke, Yi-quan
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Źródło:
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International Journal of Cancer; Nov2010, Vol. 127 Issue 9, p2222-2229, 8p
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Inhibition of tumor neovascularization has profound effects on the growth of solid tumors. Our previous studies have shown the effect of VEGF165-PE38 recombinant immunotoxin on proliferation and apoptosis in human umbilical vein endothelial cells in vitro. In this study, we explored the direct inhibition of angiogenesis in chick chorioallantoic membrane and antiangiogenic therapy in a malignant glioma model. HEK293 cells were transfected with the pVEGF165PE38-IRES2-EGFP plasmid. ELISA was used to confirm the expression of VEGF165-PE38 in the transfected cells. These cells released 1396 ± 131.9 pg VEGF165-PE38/1×10 [ABSTRACT FROM AUTHOR]
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