-
Tytuł:
-
Phase I trial of a 72-h continuous-infusion schedule of fazarabine.
-
Autorzy:
-
Amato, Robert
Ho, Dah
Schmidt, Sue
Krakoff, Irwin
Raber, Martin
Amato, R
Ho, D
Schmidt, S
Krakoff, I H
Raber, M
-
Temat:
-
ANTINEOPLASTIC agents
CLINICAL trials
COMPARATIVE studies
DRUG administration
CLINICAL drug trials
INTRAVENOUS therapy
RESEARCH methodology
MEDICAL cooperation
RESEARCH
RESEARCH funding
TUMORS
EVALUATION research
RANDOMIZED controlled trials
AZACITIDINE
THERAPEUTICS
-
Źródło:
-
Cancer Chemotherapy & Pharmacology; Jul1992, Vol. 30 Issue 4, p321-324, 4p
-
Fazarabine (Ara-AC), a structural analog derived from the antitumor nucleoside cytosine arabanoside (Ara-C) and 5-azacytidine (5-AC), was studied in a phase I clinical trial. Doses ranging from 0.2 to 2.0 mg m-2 h-1 were given intravenously over 72 h every 28 days. The maximum tolerated dose (MDT) was 2.00 mg m-2 h-1. The dose-limiting toxicity was myelosuppression, with granulocytopenia being quantitatively more important than thrombocytopenia or anemia. Nonhematologic toxicity was minimal. Associated with the solvent dimethylsulfoxide (DMSO) was a bitter taste and a garlic-like odor. [ABSTRACT FROM AUTHOR]
Copyright of Cancer Chemotherapy & Pharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)