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Tytuł pozycji:

Striatal [F]fluorodopa utilization after COMT inhibition with entacapone studied with PET in advanced Parkinson's disease.

Tytuł:
Striatal [F]fluorodopa utilization after COMT inhibition with entacapone studied with PET in advanced Parkinson's disease.
Autorzy:
Ruottinen, H.
Rinne, J.
Ruotsalainen, U.
Bergman, J.
Oikonen, V.
Haaparanta, M.
Solin, O.
Laihinen, A.
Rinne, U.
Źródło:
Journal of Neural Transmission - Parkinson's Disease & Dementia Section; Dec1995, Vol. 10 Issue 2/3, p91-106, 16p
Czasopismo naukowe
The effect of peripheral catechol-O-methyltransferase (COMT) inhibition with entacapone on striatal uptake of 6-[F]fluoro-L-dopa (FDOPA) was studied with PET both without and with entacapone in fifteen advanced parkinsonian patients and six healthy controls. Entacapone significantly enhanced the fraction of unmetabolized FDOPA in plasma from 16% to about 50% at 80 minutes after FDOPA injection in all subjects. The striatal to occipital ratios and the striatal FDOPA uptake, expressed as a modified decarboxylation coefficient (kR), was significantly increased in healthy controls, whereas in parkinsonian patients the increase was significant only in the caudate. On the other hand, the influx constant (K) decreased significantly in the caudate and putamen in parkinsonian patients; in healthy controls the K remained virtually unchanged. Effective peripheral COMT inhibition markedly increased the fraction of FDOPA in plasma and thus its availability in the brain for decarboxylation both in patients and control subjects. However, the change in striatal FDOPA uptake was modest in the advanced parkinsonian patients as compared to that in control subjects, because of the advanced disease, decreased storage capacity, or both. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Neural Transmission - Parkinson's Disease & Dementia Section is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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