Dear user, the application need JavaScript support. Please enable JavaScript in your browser.

You are browsing as a GUEST
Title of the item:

Mifepristone 2.5 mg versus 5 mg daily in the treatment of leiomyoma before surgery.

Title :
Mifepristone 2.5 mg versus 5 mg daily in the treatment of leiomyoma before surgery.
Authors :
Carbonell Esteve, Josep L.
Riverón, Ana M.
Cano, Mariela
Ortiz, Alma I.
Valle, Aleta
Texidó, Carlos S.
Tomasi, Giuseppe
Show more
Subject Terms :
SMOOTH muscle tumors
TUMOR treatment
Source :
International Journal of Women's Health; 2012, Vol. 4, p75-84, 10p
Geographic Terms :
Academic Journal
Objectives: To evaluate the efficacy and safety of 2.5 mg and 5 mg mifepristone during 3 months for the treatment of uterine fibroids before surgery. Design: Multicenter randomized clinical trial. Locations: Eusebio Hernández Hospital, Havana, Cuba and the Alemán Hospital, Managua, Nicaragua. Subjects: Included in the study were 146 women with symptomatic uterine fibroids. Treatment: Group I: half a tablet of 5 mg (2.5 mg) mifepristone taken orally every 24 hours, and Group II: one tablet of 5 mg mifepristone taken orally every 24 hours over a period of 3 months in both groups. Two endometrial biopsies were performed. Variables to evaluate efficacy: Increase in average hemoglobin, changes in fibroid and uterine volume, and symptomatic improvement. Results: The average hemoglobin at the end of treatment was 0.6 g/dL greater in the 5 mg mifepristone group (P = 0.033). In both groups there were similar reductions in fibroid volumes. Clinical improvement was more significant in the 5 mg group. Conclusion: The dose to be used should be 5 mg. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Women's Health is the property of Dove Medical Press Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

We use cookies to help identify your computer so we can tailor your user experience, track shopping basket contents and remember where you are in the order process.