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Tytuł:
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Large granular lymphocytes (LGL) following non-myeloablative allogeneic bone marrow transplantation: a case report.
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Autorzy:
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Mohty, M
Faucher, C
Gaugler, B
Vey, N
Sainty, D
Arnoulet, C
Mozziconacci, M J
Isnardon, D
Gastaut, J A
Maraninchi, D
Olive, D
Blaise, D
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Temat:
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LYMPHOCYTES
MYELOID leukemia
TUMORS
CANCER cells
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Źródło:
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Bone Marrow Transplantation; 12/15/2001, Vol. 28 Issue 12, p1157, 4p
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We report here the first case of large granular lymphocytes (LGL) expansion following non-myeloablative allo-BMT for chronic myeloid leukemia. We characterized the morphologic, phenotypic and functional features of the LGL subset amplified in vivo14 months after allo-BMT. Our results indicate that LGL can mediate in vitro a cytolytic activity on tumor cells. In vivo, the timing of the LGL expansion was associated with a sustained complete molecular remission. These observations suggest that LGL are a subset with the properties of effector lymphocytes which may contribute to the graft-versus-tumor effect.Bone Marrow Transplantation (2001) 28, 1157–1160. [ABSTRACT FROM AUTHOR]
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