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Tytuł pozycji:

Lipid profiles are associated with lesion formation over 24 months in interferon-β treated patients following the first demyelinating event.

Tytuł :
Lipid profiles are associated with lesion formation over 24 months in interferon-β treated patients following the first demyelinating event.
Autorzy :
Weinstock-Guttman, Bianca
Zivadinov, Robert
Horakova, Dana
Havrdova, Eva
Jun Qu
Shyh, Grace
Lakota, Elizabeth
O'Connor, Kerri
Badgett, Darlene
Tamaño-Blanco, Miriam
Tyblova, Michaela
Hussein, Sara
Bergsland, Niels
Willis, Laura
Krasensky, Jan
Vaneckova, Manuela
Seid, Zdenek
Ramanathan, Murali
Pokaż więcej
Temat :
DEMYELINATION
LIPID analysis
INTERFERONS
HIGH density lipoproteins
BLOOD cholesterol
DISEASE progression
THERAPEUTICS
Źródło :
Journal of Neurology, Neurosurgery & Psychiatry; Nov2013, Vol. 84 Issue 11, p1186-1191, 6p, 2 Charts, 1 Graph
Czasopismo naukowe
Objectives: To investigate the associations of serum lipid profile with disease progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. Methods: High density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were obtained in pretreatment serum from 135 high risk patients with CIS (≥2 brain MRI lesions and ≥2 oligoclonal bands) enrolled in the Observational Study of Early Interferon β-1a Treatment in High Risk Subjects after CIS study (SET study), which prospectively evaluated the effect of intramuscular interferon β-1a treatment following the first demyelinating event. Thyroid stimulating hormone, free thyroxine, 25-hydroxy vitamin D3, active smoking status and body mass index were also obtained. Clinical and MRI assessments were obtained within 4 months of the initial demyelinating event and at 6, 12 and 24 months. Results: The time to first relapse and number of relapses were not associated with any of the lipid profile variables. Higher LDL-C (p=0.006) and TC ( p=0.001) levels were associated with increased cumulative number of new T2 lesions over 2 years. Higher free thyroxine levels were associated with lower cumulative number of contrast-enhancing lesions (p=0.008). Higher TC was associated as a trend with lower baseline whole brain volume (p=0.020). Higher high density lipoprotein was associated with higher deseasonalised 1,25-dihydroxy vitamin D3 (p=0.003) levels and a trend was found for deseasonalised 25-hydroxy vitamin D3 (p=0.014). Conclusions: In early multiple sclerosis, lipid profile variables particularly LDL-C and TC levels are associated with inflammatory MRI activity measures. [ABSTRACT FROM AUTHOR]
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