Küçük hücreli akciğer kanserinde anjiogenik faktörler (VEGF, VEGFR-1, VEGFR-2). (Turkish)

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Tytuł:: Küçük hücreli akciğer kanserinde anjiogenik faktörler (VEGF, VEGFR-1, VEGFR-2). (Turkish)
Autorzy:: SOYDİNÇ, Hilal OĞUZ
DURANYILDIZ, Derya
BİLGİN, Elif
TAŞ, Faruk
YASASEVER, Vildan
Temat:: VASCULAR endothelial growth factors
SMALL cell lung cancer
PROTEIN-tyrosine kinases
CANCER cells
ENZYME-linked immunosorbent assay
ENDOTHELIAL cells
Alternatywny tytuł:: Angiogenic factors in small vell lung cancer (VEGF, VEGFR-1, VEGFR-2). (English)
Źródło:: Turkish Journal of Oncology / Türk Onkoloji Dergisi; 2012, Vol. 27 Issue 2, p55-61, 7p
Abstract (English):: OBJECTIVES Angiogenesis has an important role in metastasis. Vascular endothelial growth factor (VEGF) is one of the angiogenic factors that has the ability to increase the permeability of capillary blood vessels. Its mitogenic and angiogenic activities are specific for endothelial cells. VEGF was secreted both from normal and tumor cells. Small cell lung cancer (SCLC) is one of the main types of lung cancer that grows and spreads quickly. In this study, we investigated VEGF and its receptors VEGFR-1 (fms-related tyrosine kinase/FLT- 1) and VEGFR-2 (kinase insert domain receptor/KDR) in SCLC. METHODS Our study group consisted of 60 SCLC patients and 20 healthy subjects. The serum levels were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS Serum levels of VEGF (p<0.001) and its receptors (p<0.001) were significantly higher in patients than controls before chemotherapy. CONCLUSION Our data indicate that coexpression of serum levels of VEGF and its receptors can be used for deciding the antiangiogenic therapy. [ABSTRACT FROM AUTHOR]
: Czasopismo naukowe

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