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Tytuł pozycji:

α-Melanocyte-stimulating hormone: a protective peptide against chemotherapy-induced hair follicle damage?

Tytuł:
α-Melanocyte-stimulating hormone: a protective peptide against chemotherapy-induced hair follicle damage?
Autorzy:
Böhm, M.
Bodó, E.
Funk, W.
Paus, R.
Temat:
BALDNESS
PHYSIOLOGICAL effects of chemotherapy
HAIR follicle physiology
MSH (Hormone)
MELANOCYTES
Źródło:
British Journal of Dermatology; Apr2014, Vol. 170 Issue 4, p956-960, 5p
Czasopismo naukowe
Background Effective, safe and well-tolerated therapeutic and/or preventive regimens for chemotherapy-induced alopecia ( CIA) still remain to be developed. Because α-melanocyte-stimulating hormone (α- MSH) exerts a number of cytoprotective effects and is well tolerated, we hypothesized that it may be a candidate CIA-protective agent. Objectives To explore, using a human in vitro model for chemotherapy-induced hair follicle ( HF) dystrophy that employs the key cyclophosphamide metabolite (4-hydroperoxy-cyclophosphamide, 4- HC), whether α- MSH protects from 4- HC-induced HF dystrophy. Methods Microdissected human scalp HFs from four individuals were treated with 4- HC, α- MSH and 4- HC plus α- MSH. Changes in HF cycling, melanin distribution and hair matrix keratinocyte proliferation/apoptosis were examined by quantitative (immune-) morphometry. Expression of the cytoprotective enzyme haem oxygenase-1 ( HO-1) was determined by real-time reverse transcriptase-polymerase chain reaction in HF of two individuals. Results In 50% of the individuals α-MSH reduced melanin clumping as an early sign of 4-HC-induced disruption of follicular pigmentation. α-MSH reduced 4-HC-induced apoptosis in the HFs of one female patient. These protective effects of α-MSH were not associated with changes in 4-HC-induced catagen induction. α-MSH and 4-HC both increased HO-1 m RNA expression, while the combination of both agents had additive effects on HO-1 transcription. Conclusions Exogenous α- MSH exerts moderate HF-protective effects against 4- HC-induced human scalp HF damage and upregulates the intrafollicular expression of a key cytoprotective enzyme. However, as substantial interindividual response variations were found, further studies are needed to probe α- MSH as a candidate CIA-protective agent. [ABSTRACT FROM AUTHOR]
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