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Tytuł pozycji:

Resolution of HLA-B*44:02: 01G, - DRB1*14:01: 01G and - DQB1*03:01: 01G reveals a high allelic variability among 12 European populations.

Tytuł :
Resolution of HLA-B*44:02: 01G, - DRB1*14:01: 01G and - DQB1*03:01: 01G reveals a high allelic variability among 12 European populations.
Autorzy :
Vidan‐Jeras, B.
Buhler, S.
Dubois, V.
Grubic, Z.
Ivanova, M.
Jaatinen, T.
Ligeiro, D.
Lokki, M.‐L.
Papasteriades, C.
Poli, F.
Spyropoulou‐Vlachou, M.
Tordai, A.
Viken, M.K.
Wenda, S.
Nunes, J.M.
Sanchez‐Mazas, A.
Tiercy, J.‐M.
Pokaż więcej
Temat :
GENETIC research
POLYMERASE chain reaction
NUCLEOTIDE sequencing
HLA histocompatibility antigens
GENE amplification
HEMATOPOIETIC stem cell transplantation
EXONS (Genetics)
Źródło :
Tissue Antigens; Nov2014, Vol. 84 Issue 5, p459-464, 6p
Czasopismo naukowe
Within the framework of the EU-funded HLA-NET action, an analysis of three G-group alleles, HLA-B*44:02:01G, DRB1*14:01:01G and DQB1*03:01:01G, was undertaken in 12 European populations. Ambiguities were resolved by polymerase chain reaction-sequence-specific amplification (PCR-SSP) or PCR-sequence-based typing (PCR-SBT) in a total of 5095 individuals. The results of the DRB1*14:01/14:54 ambiguity showed high relative ratios (24-53%) of DRB1*14:01 in Bulgarians, Croatians, Greeks, Italians and Slovenians, contrasting with low ratios (6-13%) in Austrians, Finnish, French, Hungarians, Norwegians and Swiss. Resolution of the B*44:02/44:27 ambiguity showed that B*44:27 had a high relative ratio in Slovenians (25.5%) and Bulgarians (37%) and low in French and Swiss (0.02-1%), and was not observed in Greeks and Italians. The highest relative ratio of DQB1*03:19 was found in Portuguese (11%), by contrast with low ratios (0-3%) in the other five populations. Analysis of the A, B, DRB1 phenotypes and family-derived haplotypes in 1719 and 403 individuals positive for either HLA-B*44:02G or DRB1*14:01G ambiguities, respectively, showed some preferential associations, such as A*26∼DRB1*14:01, B*35∼DRB1*14:01, B*38∼DRB1*14:01 and B*44:27∼DRB1*16. Because these ambiguities are located outside the peptide-binding site, they may not be recognized by alloreactive T-cells. However, because of strong linkage disequilibrium (LD), the DRB1*14:01 vs DRB1*14:54 and the B*44:02 vs B*44:27 mismatches are associated to DRB3-, and C-mismatches, respectively. These results are informative for algorithms searching unrelated hematopoietic stem cell donors. For B*44:27-positive patients, searches are expected to be more successful when requesting donors from Southeastern-European ancestry. Furthermore, the introduction of human leukocyte antigen (HLA)-typing strategies that allow resolving exon 4 (for class I) and exon 3 (for class II) polymorphisms can be expected to contribute significantly to population genetics studies. [ABSTRACT FROM AUTHOR]
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