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Tytuł pozycji:

Intravenous bisphosphonate therapy does not thicken cementum or change periodontal ligaments of cancer patients.

Tytuł :
Intravenous bisphosphonate therapy does not thicken cementum or change periodontal ligaments of cancer patients.
Autorzy :
de Pauli Paglioni, Mariana
Gomes Silva, Wagner
Pereira, Juliana
Migliorati, César Augusto
Lopes, Marcio Ajudarte
de Almeida, Oslei Paes
Goes, Mario Fernando
Ribeiro, Ana Carolina Prado
Brandão, Thais Bianca
Santos-Silva, Alan Roger
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Źródło :
Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology; May2017, Vol. 123 Issue 5, p591-599, 9p
Czasopismo naukowe
Objective: To test the hypothesis that intravenous (IV) bisphosphonate (BP) therapy thickens or alters the micromorphology of cementum and periodontal ligament (PDL) in cancer patients.Study Design: Thirty-two teeth extracted from 24 cancer patients and separated into test (patients who have undergone IV BP therapy, n = 16) and control (patients naive to BP therapy, n = 16) groups were studied. Cementum thickness was measured in 3 different areas of the dental root with polarized light microscopy. PDL was assessed by optical light microscopy and the immunohistochemical expression of periostin.Results: No significant difference was detected in cementum thickness (apical, P = .06; medium, P = .16; cervical, P = .18) between groups. The numbers of fibroblasts in PDL (P = .56), incremental lines of cementum (P = .51) and the immunohistochemical patterns of periostin expression in PDL (P = .68) did not differ between groups.Conclusion: IV BP therapy does not thicken cementum or change the micromorphology of PDL. [ABSTRACT FROM AUTHOR]
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