- Tytuł:
- Pre-pubertal onset of type 1 diabetes and appearance of retinopathy.
- Autorzy:
- Temat:
-
PUBERTY
RETROLENTAL fibroplasia
DIABETES
INSULIN
ENDOCRINE diseases - Źródło:
- Diabetes & Metabolism; Jun2004, Vol. 30 Issue 3, p229-233, 5p
- Abstract (English):
- Summary: Objectives: It was suggested that the years of diabetes preceding puberty may not contribute to the development of retinopathy but evidence for this is conflicting. To verify the influence of pre-pubertal diabetes, we compared the correlations between prevalence of retinopathy and diabetes duration in patients who developed type 1 diabetes before and after puberty. Methods: Six hundred and twenty-eight patients with diabetes onset at age ≤ 29, on insulin treatment and aged ≤ 60 at the time of screening for retinopathy were considered retrospectively. Pre-pubertal age was defined as 0-12 in males and 0-11 in females. Two hundred patients had developed diabetes before puberty and 428 after puberty. Screening was by ophthalmoscopy + 35 mm photography or digital photography. Results: Prevalence of retinopathy was lower among patients with pre-pubertal onset and diabetes durations 10-14 and 15-19 years (p = 0.006 and p = 0.003, respectively) but prevalence rates became similar after 20 yrs duration. Conclusion: That retinopathy is infrequent and mild during childhood, is probably due to the short duration of diabetes rather than a specific protective effect of pre-puberty. After 20 years'' duration, however, the prevalence of retinopathy is no longer influenced by age at onset, suggesting that, in the longer term, pre-pubertal years do contribute to the onset of retinopathy. [Copyright &y& Elsevier]
- Czasopismo naukowe
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