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Tytuł pozycji:

Combined assessment of xerostomia in head and neck cancer patients treated with surgery and postoperative intensity-modulated radiotherapy or conventional radiotherapy. (English)

Tytuł :
Combined assessment of xerostomia in head and neck cancer patients treated with surgery and postoperative intensity-modulated radiotherapy or conventional radiotherapy. (English)
Autorzy :
Yan Chao
Wang Zhong-he
Jin Ye-ning
Hu Hai-sheng
Shi Hui-feng
Pokaż więcej
Temat :
PATIENTS
SURGERY
HEAD surgery
HEAD & neck cancer
NECK surgery
RADIOTHERAPY
Źródło :
China Journal of Oral & Maxillofacial Surgery; 2009, Vol. 7 Issue 5, p401-406, 6p, 5 Charts
Terminy geograficzne :
SHANGHAI (China)
CHINA
Czasopismo naukowe
PURPOSE: This prospective longitudinal study was aimed to evaluate xerostomia in head and neck cancer patients treated with surgery followed by intensity-modulated radiotherapy (IMRT) or conventional radiotherapy (CRT). METHODS: 82 head and neck eancer patients who received surgery and postoperative radiotherapy were enrolled in this study. For radiation techniques, 40 patients were treated with IMRT and 42 patients were treated with CRT. The xerostomia was evaluated using combined methods at 5 time points before and after RT. SPSS13.0 software package was used for statistical analysis. RESULTS: The mean dose of the parotids in IMRT patients (22.21±5.02Gy) was significantly lower than that in CRT patients (50.22±5.86Gy) (P<0.01). At 6-month after radiotherapy, the rates of moderate and severe xerostomia in patients with IMRT and CRT were 30% and 92.9%,respectively, according to criteria of Radiation Therapy Ontology Group (RTOG); 25% and 90.5%, respectively, according to criteria of Shanghai Ninth People's Hospital; 15% and 83.3%, respectively, according to scores of xerostomia questionnaire (XQ) (all P<0.01). The mean unstimulated and stimulated salivary flow rates in patients with IMRT at 6-month were 51.0% and 72.5%, respectively, compared with pre-radiation levels. Those in patients with CRT were 3.6% and 8.2%, respectively. The subjective score of criteria of Shanghai Ninth People's Hospital for xerostomia was in consistent the objective result from the saliva flow rate measurement (r=0.79 and 0.78, respectively, P<0.01). CONCLUSIONS: Postoperative IMRT reduces significantly postradiation xerostomia in the study. The criteria of Shanghai Ninth People's Hospital is easy to use, and it should be recommended for evaluation of xerostomia. Supported by Research Fund of Science and Technology Commission of Shanghai Municipality (Grant No.08DZ2271100). [ABSTRACT FROM AUTHOR]
Copyright of China Journal of Oral & Maxillofacial Surgery is the property of Shanghai Jiao Tong University, College of Stomatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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