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Tytuł pozycji:

Tolerability of risedronate in postmenopausal women intolerant of alendronate

Tytuł :
Tolerability of risedronate in postmenopausal women intolerant of alendronate
Autorzy :
Adachi, J.
Adami, S.
Miller, P.
Olszynski, W.
Kendler, D.
Silverman, S.
Licata, A.
Li, Z.
Gomez-Panzani, E.
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Źródło :
Aging: Clinical and Experimental Research; October 2001, Vol. 13 Issue: 5 p347-354, 8p
Periodyk
Bisphosphonates are effective treatments for osteoporosis, but some have been associated with upper gastrointestinal intolerance. This randomized, double-blind study assessed the upper gastrointestinal tolerability of risedronate in post-menopausal women who had discontinued alen- dronate treatment because of upper gastrointestinal adverse events. Sixty-six women who had previously discontinued treatment with alendronate 10 mg/day because of upper gastrointestinal symptoms received placebo (N=31) or risedronate 5 mg (N=35) daily for 3 months. The primary outcome was the rate of discontinuation due to upper gastrointestinal adverse events: 5/31 (16.1%) in the placebo group, and 4/35 (11.4%) in the risedronate group. Discontinuation rates were also similar in the two treatment groups among subgroups of patients with a history of gastrointestinal disorder, prior use of acid suppression drugs, and concomitant use of NSAIDs. The overall incidence of upper gastrointestinal events was comparable between the placebo (19.4%) and risedronate (20.0%) groups. Overall, risedronate 5 mg/day for 3 months was as well tolerated as placebo in patients who could not tolerate alendronate 10 mg. These results are consistent with, and complement those from previous studies showing that risedronate 5 mg has a gastrointestinal tolerability similar to that of placebo.

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