More than 70% of patients with neurofibromatosis type 1 (NF-1), present hyperintense foci in MR DP-T2 weighted images, located in deep grey and white matter.The true nature of these hyperintense foci is still unknown: they could be hamartomas, that is composition and organisation alterated areas of cytologic normal tissue, gliotic areas, delayed or disorganised areas of myelinisation and, finally, low grade glial tumors (astrocytoma).We present the case of a 17 years old pazient, who underwent 8 MR brain studies in a six years period.We analyzed the MR characteristics of the hyperintense foci in seriated studies and, particularly, the evolution of a single, simple, hyperintense periventricular lesion in cistic tumor with intramural nodule.
