This study investigated the contribution of climate change to the growth of agro-based small scale industries in Ondo state Nigeria. The secondary data utilized were derived from the study of the interrelationship between changing climate and access to raw materials needed for production. Two hundred enterprises were sampled and results analyzed across the regions of the state. The study established that, climate change has reduced the country’s arable land and has made access to raw materials difficult and unpredictable leading to collapse of many enterprises. The study also discovered that many of surviving enterprises have had to build their own supply chains by establishing their own farms, reduce production and workforce, leading to low capacity utilization and shortage of processed food and raw materials to industries. The study concluded that the problem could be mitigated through better management of arable and wetlands, enlightenment of manufacturers and processors on coping strategies and improved support from government bodies.