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Tytuł pozycji:

Correlation study between osteoporosis and hematopoiesis in the context of adjuvant chemotherapy for breast cancer

Tytuł :
Correlation study between osteoporosis and hematopoiesis in the context of adjuvant chemotherapy for breast cancer
Autorzy :
Naveiras, Olaia
Schyrr, Frédérica
Wolfer, Anita
Pasquier, Jérôme
Nicoulaz, Anne-Laure
Lamy, Olivier
Pokaż więcej
Temat :
TBS
Bone marrow microenvironment
Bone marrow adipocytes
Breast cancer
Osteoblast
Febrile neutropenia
Osteoporosis
Chemotherapy
Neutrophil
Anemia
Graded toxicity of chemotherapy
Original Article
Hematopoiesis
Stress hematopoiesis
Trabecular bone score
T-score
Platelet
Absorptiometry, Photon
Adipocytes/drug effects
Adipocytes/immunology
Adipocytes/pathology
Adult
Aged
Antineoplastic Agents/administration & dosage
Antineoplastic Agents/adverse effects
Blood Platelets/drug effects
Blood Platelets/immunology
Blood Platelets/pathology
Body Mass Index
Bone Density/drug effects
Bone Density/immunology
Bone Diseases, Metabolic/complications
Bone Diseases, Metabolic/diagnostic imaging
Bone Diseases, Metabolic/drug therapy
Bone Diseases, Metabolic/immunology
Bone Marrow Cells/drug effects
Bone Marrow Cells/immunology
Bone Marrow Cells/pathology
Breast Neoplasms/complications
Breast Neoplasms/diagnostic imaging
Breast Neoplasms/drug therapy
Breast Neoplasms/immunology
Cell Count
Chemotherapy, Adjuvant
Female
Hematopoiesis/drug effects
Hematopoiesis/immunology
Humans
Lumbar Vertebrae/diagnostic imaging
Lumbar Vertebrae/drug effects
Lumbar Vertebrae/immunology
Lumbar Vertebrae/pathology
Middle Aged
Neutropenia/chemically induced
Neutropenia/diagnostic imaging
Neutropenia/immunology
Neutropenia/pathology
Neutrophils/drug effects
Neutrophils/immunology
Neutrophils/pathology
Osteoblasts/drug effects
Osteoblasts/immunology
Osteoblasts/pathology
Osteoporosis/complications
Osteoporosis/diagnostic imaging
Osteoporosis/drug therapy
Osteoporosis/immunology
Retrospective Studies
Źródło :
Annals of hematology, vol. 97, no. 2, pp. 309-317
Wydawca :
Springer Verlag, 2017.
Rok publikacji :
2017
Oryginalny identyfikator :
pmc: PMC5754401
pmid: 29170810
Opis pliku :
application/pdf
ISSN :
1432-0584
0939-5555
DOI :
10.1007/s00277-017-3184-6
This retrospective study attempts to establish if a correlation exists between osteoporosis and hematopoiesis before and after adjuvant chemotherapy in the context of non-metastatic breast cancer. Osteoporosis is interpreted both as a direct marker of osteoblastic decline and as an indirect marker of increased bone marrow adiposity within the hematopoietic microenvironment. Patients from the "Centre du Sein" at CHUV (Centre Hospitalier Universitaire Vaudois) undergoing adjuvant chemotherapy were included in this study. Evolution of blood counts was studied in correlation with the osteoporosis status. Toxicity of chemotherapy was coded according to published probability of febrile neutropenia. One hundred forty-three women were included: mean age 52.1 ± 12.5 years, mean BMI (body mass index) 24.4 ± 4.1. BMD (bone mineral density) scored osteoporotic in 32% and osteopenic in 45%. Prior to chemotherapy, BMD was positively correlated with neutrophil (p < 0.001) and thrombocyte (p = 0.01) count; TBS (trabecular bone score) was not correlated with blood count. After the first cycle of chemotherapy, an increase of one point in TBS correlated with a decrease of 57% on the time to reach leucocyte nadir (p = 0.004). There was a positive correlation between BMD and risk of infection (p < 0.001). Our data demonstrates an association between osteoporosis and lower blood counts in a younger cohort than previously published, extending it for the first time to neutrophil counts in females. Our results suggest that the healthier the bone, the earlier the lowest leucocyte count value, prompting further research on this area.

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