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Tytuł pozycji:

Influenza vaccine effectiveness estimates in Europe in a season with three influenza type/subtypes circulating: the I-MOVE multicentre case–control study, influenza season 2012/13

Tytuł :
Influenza vaccine effectiveness estimates in Europe in a season with three influenza type/subtypes circulating: the I-MOVE multicentre case–control study, influenza season 2012/13
Autorzy :
Kissling, E.
Valenciano, M.
Buchholz, Udo
Larrauri, A.
Cohen, J. M.
Nunes, B.
Rogalska, J.
Pitigoi, D.
Paradowska-Stankiewicz, I.
Reuss, Annicka
Jiménez-Jorge, S.
Daviaud, I.
Guiomar, R.
O’Donnell, J.
Necula, Gheorghe
Głuchowska, M.
Moren, A.
Pokaż więcej
Temat :
Influenza Vaccines/administration & dosage
Infant Newborn
Influenza A Virus H3N2 Subtype/isolation & purification
Young Adult
Influenza Human/prevention & control
Influenza A Virus H1N1 Subtype/isolation & purification
Influenza B virus/isolation & purification
Infant
610 Medizin
Influenza B virus/immunology
Influenza Human/virology
respiratory tract diseases
Population Surveillance
Pandemics/prevention & control
ddc:610
Female
Case-Control Studies
Logistic Models
Influenza Vaccines/immunology
Seasons
Aged
Sentinel Surveillance
Middle Aged
Vaccination/statistics & numerical data
Sensitivity and Specificity
Influenza A Virus H1N1 Subtype/immunology
Influenza Human/epidemiology
Outcome Assessment (Health Care)
Adolescent
Europe/epidemiology
European Union
virus diseases
Preschool
Influenza A Virus H3N2 Subtype/immunology
Adult
Humans
Male
Child
Wydawca :
Robert Koch-Institut, Infektionsepidemiologie, 2014.
Rok publikacji :
2014
Kolekcja :
Publikationsserver_des_Robert_Koch-Instituts_enriched
Datacite
Datacite_enriched
Publikationsserver_des_Robert_Koch-Instituts
Opis pliku :
application/pdf
Język :
English
DOI :
10.25646/1747
Numer akcesji :
edsair.dedup.wf.001..1683cc425cef0d62297ed2621dce88df
In the fifth season of Influenza Monitoring Vaccine Effectiveness in Europe (I-MOVE), we undertook a multicentre case–control study (MCCS) in seven European Union (EU) Member States to measure 2012/13 influenza vaccine effectiveness against medically attended influenza-like illness (ILI) laboratory confirmed as influenza. The season was characterised by substantial co-circulation of influenza B, A(H1N1)pdm09 and A(H3N2) viruses. Practitioners systematically selected ILI patients to swab ≤7 days of symptom onset. We compared influenza-positive by type/subtype to influenza-negative patients among those who met the EU ILI case definition. We conducted a complete case analysis using logistic regression with study as fixed effect and calculated adjusted vaccine effectiveness (AVE), controlling for potential confounders (age, sex, symptom onset week and presence of chronic conditions). We calculated AVE by type/subtype. Study sites sent 7,954 ILI/acute respiratory infection records for analysis. After applying exclusion criteria, we included 4,627 ILI patients in the analysis of VE against influenza B (1,937 cases), 3,516 for A(H1N1)pdm09 (1,068 cases) and 3,340 for influenza A(H3N2) (730 cases). AVE was 49.3% (95% confidence interval (CI): 32.4 to 62.0) against influenza B, 50.4% (95% CI: 28.4 to 65.6) against A(H1N1)pdm09 and 42.2% (95% CI: 14.9 to 60.7) against A(H3N2). Our results suggest an overall low to moderate AVE against influenza B, A(H1N1)pdm09 and A(H3N2), between 42 and 50%. In this season with many co-circulating viruses, the high sample size enabled stratified AVE by type/subtype. The low estimates indicate seasonal influenza vaccines should be improved to achieve acceptable protection levels.

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