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Title of the item:

Poles Apart: Prokaryotic Polar Organelles and Their Spatial Regulation

Title :
Poles Apart: Prokaryotic Polar Organelles and Their Spatial Regulation
Authors :
Kirkpatrick, Clare
Viollier, Patrick
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Subject Terms :
Fimbriae, Bacterial/physiology
Organelles/physiology/ultrastructure
Perspectives
ddc:616
Cell Polarity/physiology
Cell Movement/physiology
Polysaccharides/metabolism
Prokaryotic Cells/cytology
Molecular Motor Proteins/metabolism
Bacterial Proteins/physiology
Ras Proteins/metabolism
Source :
Cold Spring Harbor Perspectives in Biology, Vol. 3, No 3 (2011)
Publisher :
Cold Spring Harbor Laboratory Press, 2011.
Publication Year :
2011
Original Identifier :
pmc: PMC3039935
pmid: 21084387
Language :
English
ISSN :
1943-0264
DOI :
10.1101/cshperspect.a006809
While polar organelles hold the key to understanding the fundamentals of cell polarity and cell biological principles in general, they have served in the past merely for taxonomical purposes. Here, we highlight recent efforts in unraveling the molecular basis of polar organelle positioning in bacterial cells. Specifically, we detail the role of members of the Ras-like GTPase superfamily and coiled-coil-rich scaffolding proteins in modulating bacterial cell polarity and in recruiting effector proteins to polar sites. Such roles are well established for eukaryotic cells, but not for bacterial cells that are generally considered diffusion-limited. Studies on spatial regulation of protein positioning in bacterial cells, though still in their infancy, will undoubtedly experience a surge of interest, as comprehensive localization screens have yielded an extensive list of (polarly) localized proteins, potentially reflecting subcellular sites of functional specialization predicted for organelles.

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