Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

Effects of the Fruit Extract of Tribulus terrestris on Skin Inflammation in Mice with Oxazolone-Induced Atopic Dermatitis through Regulation of Calcium Channels, Orai-1 and TRPV3, and Mast Cell Activation

Tytuł :
Effects of the Fruit Extract of Tribulus terrestris on Skin Inflammation in Mice with Oxazolone-Induced Atopic Dermatitis through Regulation of Calcium Channels, Orai-1 and TRPV3, and Mast Cell Activation
Autorzy :
Park, Yong-Ki
Bae, Hyo Sang
Kang, Seok Yong
Jung, Hyo Won
Nam, Joo Hyun
Kim, Woo Kyung
Kang, Jong-Seong
Kim, Young-Ho
Cho, Cheong-Weon
Cho, Chong Woon
Pokaż więcej
Temat :
Other systems of medicine
Research Article
RZ201-999
Article Subject
Źródło :
Evidence-Based Complementary and Alternative Medicine, Vol 2017 (2017)
Evidence-based Complementary and Alternative Medicine : eCAM
Wydawca :
Hindawi Limited, 2017.
Rok publikacji :
2017
Kolekcja :
Hindawi_Publishing_Corporation
DOAJ-Articles_enriched
DOAJ-Articles
Hindawi_Publishing_Corporation_enriched
Oryginalny identyfikator :
pmc: PMC5733837
pmid: 29348776
Opis pliku :
text/xhtml
Język :
English
ISSN :
1741-4288
1741-427X
DOI :
10.1155/2017/8312946
Ethnopharmacological Relevance. In this study, we investigated the effects of Tribulus terrestris fruit (Leguminosae, Tribuli Fructus, TF) extract on oxazolone-induced atopic dermatitis in mice. Materials and Methods. TF extract was prepared with 30% ethanol as solvent. The 1% TF extract with or without 0.1% HC was applied to the back skin daily for 24 days. Results. 1% TF extract with 0.1% HC improved AD symptoms and reduced TEWL and symptom scores in AD mice. 1% TF extract with 0.1% HC inhibited skin inflammation through decrease in inflammatory cells infiltration as well as inhibition of Orai-1 expression in skin tissues. TF extract inhibited Orai-1 activity in Orai-1-STIM1 cooverexpressing HEK293T cells but increased TRPV3 activity in TRPV3-overexpressing HEK293T cells. TF extract decreased β-hexosaminidase release in RBL-2H3 cells. Conclusions. The present study demonstrates that the topical application of TF extract improves skin inflammation in AD mice, and the mechanism for this effect appears to be related to the modulation of calcium channels and mast cell activation. This outcome suggests that the combination of TF and steroids could be a more effective and safe approach for AD treatment.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies