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Tytuł pozycji:

Insulin-like growth factor I promotes cord blood T cell maturation through monocytes and inhibits their apoptosis in part through interleukin-6

Tytuł :
Insulin-like growth factor I promotes cord blood T cell maturation through monocytes and inhibits their apoptosis in part through interleukin-6
Autorzy :
Lau Yu
Tu Wenwei
Liu Enmei
Law Helen KW
Pokaż więcej
Temat :
RC581-607
Research Article
Insulin-Like Growth Factor I - immunology - metabolism
Antigens, CD95 - genetics - immunology - metabolism
Cell Differentiation - immunology
Antigens, CD45 - genetics - immunology - metabolism
Immunologic diseases. Allergy
Interleukin-6 - immunology - metabolism
Immunology
Źródło :
BMC Immunology, Vol 9, Iss 1, p 74 (2008)
Wydawca :
United Kingdom, 2008.
Rok publikacji :
2008
Kolekcja :
DOAJ-Articles_enriched
HKU_Scholars_Hub
DOAJ-Articles
HKU_Scholars_Hub_enriched
Oryginalny identyfikator :
pmc: PMC2631546
pmid: 19091070
Język :
English
ISSN :
1471-2172
DOI :
10.1186/1471-2172-9-74
Background The functional immaturity of T cells contributes to the susceptibility of neonates to infections and the less severe graft-versus-host disease associated with cord blood (CB) transplantation. We have previously reported that insulin-like growth factor – I (IGF-I) promotes the phytohaemagglutinin (PHA)-induced CB T cell maturation and inhibits their apoptosis in mononuclear cell (MC) culture. We hypothesized that the effects of IGF-I may be mediated by accessory cells and soluble factors. Results This study showed that the kinetics of PHA-induced maturation in purified CD3+ T cell was delayed compared to that in CBMC. The addition of autologous CD14+ monocytes increased T cell maturation and potentiated the effect of IGF-I. The addition of IL-6 had no effect on CB T cell maturation but it reduced PHA-induced apoptosis significantly. We further demonstrated that the neutralisation of IL-6 in CBMC culture partially abrogated the anti-apoptotic effect of IGF-1 on T cells. The anti-apoptotic effect of IL-6 was not mediated via the reduction of Fas expression in T cell subsets. Conclusion Our results suggested that the maturation effect of IGF-1 is partially mediated by monocytes and the anti-apoptotic effect in part via IL-6. Further investigation is needed to explore the therapeutic use of IGF-I in enhancing neonatal immunity.

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