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Tytuł pozycji:

Growth differentiation factor-15 and fibroblast growth factor-23 are associated with mortality in type 2 diabetes – An observational follow-up study

Tytuł :
Growth differentiation factor-15 and fibroblast growth factor-23 are associated with mortality in type 2 diabetes – An observational follow-up study
Autorzy :
Frimodt-Møller, Marie
von Scholten, Bernt Johan
Reinhard, Henrik
Jacobsen, Peter Karl
Hansen, Tine Willum
Persson, Frederik Ivar
Parving, Hans-Henrik
Rossing, Peter
Pokaż więcej
Temat :
Growth Differentiation Factor 15/blood
Research Support, Non-U.S. Gov't
Observational Study
Cardiovascular Diseases/diagnosis
Fibroblast Growth Factor
Female
Fibroblast Growth Factors/blood
Metabolic Disorders
Risk Factors
Biology and Life Sciences
Growth Factors
Glomerular Filtration Rate
Biomarkers
Physiology
Science
Renal System
Male
Proportional Hazards Models
Endocrinology
Chronic Kidney Disease
Research Article
Kaplan-Meier Estimate
Anatomy
Cardiovascular Medicine
Cause of Death
Diabetes Mellitus
Renal Insufficiency, Chronic/diagnosis
Kidneys
Endocrine Disorders
Nephrology
Endocrine Physiology
Aged
Medicine
Middle Aged
Cardiovascular Diseases
Follow-Up Studies
Type 2 Diabetes
Albuminuria/complications
Biochemistry
Journal Article
Medicine and Health Sciences
Diabetes Mellitus, Type 2/complications
Humans
Incidence
Źródło :
Frimodt-Møller, M, von Scholten, B J, Reinhard, H, Jacobsen, P K, Hansen, T W, Persson, F I, Parving, H-H & Rossing, P 2018, ' Growth differentiation factor-15 and fibroblast growth factor-23 are associated with mortality in type 2 diabetes : An observational follow-up study ', PLoS ONE, vol. 13, no. 4, e0196634 . https://doi.org/10.1371/journal.pone.0196634
PLoS ONE, Vol 13, Iss 4, p e0196634 (2018)
Wydawca :
Public Library of Science, 2018.
Rok publikacji :
2018
Kolekcja :
DOAJ-Articles_enriched
DOAJ-Articles
Oryginalny identyfikator :
pmc: PMC5919646
pmid: 29698460
Opis pliku :
application/pdf
Język :
English
ISSN :
1932-6203
DOI :
10.1371/journal.pone.0196634
OBJECTIVES: Two biomarkers, growth differentiation factor 15 (GDF-15) and fibroblast growth factor 23 (FGF-23)), reflecting different aspects of renal pathophysiology, were evaluated as determinants of decline in estimated glomerular filtration rate (eGFR), incident cardiovascular disease (CVD) and all-cause mortality in patients with type 2 diabetes (T2D) and microalbuminuria, but without clinical cardiac disease.MATERIALS AND METHODS: Prospective study including 200 T2D patients. The predefined endpoint of chronic kidney disease (CKD) progression: A decline in eGFR of >30% at any time point during follow-up. Hazard ratios (HR) are provided per 1 SD increment of log2-transformed values.RESULTS: Mean (± SD) age was 59 ± 9 years, eGFR 91.1 ± 18.3 ml/min/1.73m2 and median (IQR) UAER 103 (39-230) mg/24-h. During a median 6.1 years follow-up, 40 incident CVD events, 26 deaths and 42 patients reached the CKD endpoint after median 4.9 years. Higher GDF-15 was a determinant of decline in eGFR >30% and all-cause mortality in adjusted models (HR 1.7 (1.1-2.5); p = 0.018 and HR 1.9 (1.2-2.9); p = 0.003, respectively). Adding GDF-15 to traditional risk factors improved risk prediction of decline in renal function (relative integrated discrimination improvement (rIDI) = 30%; p = 0.037). Higher FGF-23 was associated with all-cause mortality in adjusted models (HR 1.6 (1.1-2.2); p = 0.011) with a rIDI of 30% (p = 0.024).CONCLUSIONS: In patients with T2D and microalbuminuria, higher GDF-15 and FGF-23 were independently associated with all-cause mortality and higher GDF-15 improved risk prediction of decline in kidney function and higher FGF-23 of all-cause mortality, beyond traditional risk factors, but not independently of GDF-15.
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