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Tytuł pozycji:

Increasing fat content from 20 to 45 wt% in a complex diet induces lower endotoxemia in parallel with an increased number of intestinal goblet cells in mice

Tytuł :
Increasing fat content from 20 to 45 wt% in a complex diet induces lower endotoxemia in parallel with an increased number of intestinal goblet cells in mice
Autorzy :
Benoit, B.
Laugerette, Fabienne
Plaisancie, P.
Geloen, Alain
Bodennec, J.
Estienne, Magalie
Pineau, G.
Bernalier-Donadille, A.
Vidal, H.
Michalski, Marie‐Caroline
Pokaż więcej
Temat :
Goblet Cells/*metabolism
Endotoxemia/*physiopathology
Weight Gain
Inflammation/*physiopathology
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Colon/metabolism
Mice
Triglycerides/blood
High-Fat
Occludin/metabolism
Animals
Diet
food and beverages
White/metabolism
Lipopolysaccharides
Intestines/cytology/metabolism
Inbred C57BL
Adiponectin/blood
lipids (amino acids, peptides, and proteins)
Adipose Tissue
Leptin/blood
Interleukin-6/blood
Fat-Restricted
Liver/metabolism
Dietary Fats/*administration & dosage
[SDV]Life Sciences [q-bio]
Male
Zonula Occludens-1 Protein/metabolism
Źródło :
Nutrition Research, Elsevier, 2015, 35 (4), pp.346-356. ⟨10.1016/j.nutres.2015.01.005⟩
Nutrition Research, Elsevier, 2015, 35 (4), pp.346-56. ⟨10.1016/j.nutres.2015.01.005⟩
Wydawca :
Elsevier, 2015.
Rok publikacji :
2015
Kolekcja :
INRIA_a_CCSD_electronic_archive_server_enriched
INRIA_a_CCSD_electronic_archive_server
Hyper_Article_en_Ligne_enriched
Hyper_Article_en_Ligne
Język :
English
ISSN :
0271-5317
DOI :
10.1016/j.nutres.2015.01.005
Numer akcesji :
edsair.dedup.wf.001..45b2755201a919d2814b80c33aeddd12
International audience; The impacts of high-fat diets (HFDs) on the onset of metabolic endotoxemia and low-grade inflammation are well established in rodent models. However, the dose-effect of dietary lipid intakes on these parameters is not known. We hypothesized that increasing dietary lipid amounts could be linked to parallel increases of endotoxemia, low-grade inflammation, and metabolic and intestinal alterations. Six-week-old male C57BL/6J mice were fed a low-fat diet (LFD, 2.6 wt% of lipids), a moderate HFD (mHFD, 22 wt% of lipids), or a very HFD (vHFD, 45 wt% of lipids) formulated mainly using chow ingredients and milk fat. After 12 weeks, white adipose tissues, liver, intestine, distal colon contents, and plasma were collected. Only vHFD mice significantly increased body weight and fat mass vs LFD mice. This was associated with increases of plasma concentrations of triglycerides, leptin and adiponectin, and liver lipids. No such differences were observed between LFD and mHFD mice. However, mHFD developed metabolic endotoxemia and inflammation, unlike vHFD mice. In turn, vHFD mice showed more goblet cells in all intestine segments vs both other groups and a decrease of Bacteroides-Prevotella in their microbiota vs LFD mice. Finally, mHFD mice colon exhibited a decrease in lactobacilli and in the levels of occludin phosphorylation. Altogether, using complex HFD, no associations were observed between dietary lipid amounts and the magnitude of endotoxemia, inflammation, and physiological alterations developed. These results reveal the impact of the diet composition on intestinal goblet cells and mucus coat, bringing new insights about further consequences on HFD-induced metabolic disorders.

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