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Tytuł pozycji:

Mood disorders and circulating levels of inflammatory markers in a longitudinal population-based study

Tytuł :
Mood disorders and circulating levels of inflammatory markers in a longitudinal population-based study
Autorzy :
Glaus, J.
von Känel, R.
Lasserre, A.M.
Strippoli, M.F.
Vandeleur, C.L.
Castelao, E.
Gholam-Rezaee, M.
Marangoni, C.
Wagner, E.N.
Marques-Vidal, P.
Waeber, G.
Vollenweider, P.
Preisig, M.
Merikangas, K.R.
Pokaż więcej
Temat :
Klinik für Konsiliarpsychiatrie und Psychosomatik
Adult
Aged
Biomarkers/blood
C-Reactive Protein/analysis
Depressive Disorder, Major/blood
Depressive Disorder, Major/epidemiology
Female
Humans
Inflammation/blood
Interleukin-6/blood
Linear Models
Logistic Models
Longitudinal Studies
Male
Middle Aged
Psychiatric Status Rating Scales
Switzerland/epidemiology
Tumor Necrosis Factor-alpha/blood
Atypical depression
C-reactive protein
cardiovascular risk factors
mood disorders
pro-inflammatory cytokines
prospective study
610 Medicine & health
Źródło :
Psychological medicine, vol. 48, no. 6, pp. 961-973
Glaus, J; von Känel, R; Lasserre, A M; Strippoli, M-P F; Vandeleur, C L; Castelao, E; Gholam-Rezaee, M; Marangoni, C; Wagner, E-Y N; Marques-Vidal, P; Waeber, G; Vollenweider, P; Preisig, M; Merikangas, K R (2018). Mood disorders and circulating levels of inflammatory markers in a longitudinal population-based study. Psychological Medicine, 48(06):961-973.
Wydawca :
Cambridge University Press, 2018.
Rok publikacji :
2018
Kolekcja :
Serveur_academique_lausannois_enriched
Datacite
Zurich_Open_Repository_and_Archive_enriched
Datacite_enriched
Serveur_academique_lausannois
Zurich_Open_Repository_and_Archive
Oryginalny identyfikator :
pmid: 28929992
Opis pliku :
application/pdf
Język :
English
ISSN :
1469-8978
DOI :
10.1017/s0033291717002744
Background There has been increasing evidence that chronic low-grade inflammation is associated with mood disorders. However, the findings have been inconsistent because of heterogeneity across studies and methodological limitations. Our aim is to prospectively evaluate the bi-directional associations between inflammatory markers including interleukin (IL)-6, tumor necrosis factor (TNF)-α and high sensitivity C-reactive protein (hsCRP) with mood disorders. Methods The sample consisted of 3118 participants (53.7% women; mean age: 51.0, s.d. 8.8 years), randomly selected from the general population, who underwent comprehensive somatic and psychiatric evaluations at baseline and follow-up (mean follow-up duration = 5.5 years, s.d. 0.6). Current and remitted mood disorders including bipolar and major depressive disorders (MDD) and its subtypes (atypical, melancholic, combined atypical and melancholic, and unspecified) were based on semi-structured diagnostic interviews. Inflammatory biomarkers were analyzed in fasting blood samples. Associations were tested by multiple linear and logistic regression models. Results Current combined MDD [β = 0.29, 95% confidence interval (CI) 0.03–0.55] and current atypical MDD (β = 0.32, 95% CI 0.10–0.55) at baseline were associated with increased levels of hsCRP at follow-up. There was little evidence for inflammation markers at baseline predicting mood disorders at follow-up. Conclusions The prospective unidirectional association between current MDD subtype with atypical features and hsCRP levels at follow-up suggests that inflammation may be a consequence of this condition. The role of inflammation, particularly hsCRP that is critically involved in cardiovascular diseases, warrants further study. Future research that examines potential influences of medications on inflammatory processes is indicated.

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