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Tytuł pozycji:

The Ratio of ADP- to TRAP-Induced Platelet Aggregation Quantifies P2Y(12)-Dependent Platelet Inhibition Independently of the Platelet Count

Tytuł :
The Ratio of ADP- to TRAP-Induced Platelet Aggregation Quantifies P2Y(12)-Dependent Platelet Inhibition Independently of the Platelet Count
Autorzy :
Olivier, Christoph B.
Meyer, Melanie
Bauer, Hans
Schnabel, Katharina
Weik, Patrick
Zhou, Qian
Bode, Christoph
Moser, Martin
Diehl, Philipp
Pokaż więcej
Temat :
Lipids
Research Article
Pharmaceutics
Anatomy
Cardiovascular Procedures
Diabetes Mellitus
Endocrine Disorders
Platelet Activation
Platelet Aggregation
Body Weight
Cholesterol
ddc:610
Cellular Types
Metabolic Disorders
Biology and Life Sciences
Surgical and Invasive Medical Procedures
Drug Therapy
Blood Coagulation
Physiology
Blood Cells
Animal Cells
Medicine
Body Fluids
Antiplatelet Therapy
Blood
Platelets
Medizin
Hematology
Cell Biology
Physiological Parameters
Coronary Stenting
Stent Implantation
Biochemistry
Science
Medicine and Health Sciences
Endocrinology
Źródło :
PLoS ONE, Vol 11, Iss 2, p e0149053 (2016)
Wydawca :
Ludwig-Maximilians-Universität München, 2016.
Rok publikacji :
2016
Kolekcja :
DOAJ-Articles_enriched
Open_Access_LMU_enriched
DOAJ-Articles
Open_Access_LMU
Oryginalny identyfikator :
pmc: PMC4757031
pmid: 26885820
Opis pliku :
application/pdf
Język :
English
ISSN :
1932-6203
DOI :
10.1371/journal.pone.0149053
Objective This study aimed to assess the association of clinical factors with P2Y(12)-dependent platelet inhibition as monitored by the ratio of ADP-to TRAP-induced platelet aggregation and conventional ADP-induced aggregation, respectively. Background Controversial findings to identify and overcome high platelet reactivity (HPR) after coronary stent-implantation and to improve clinical outcome by tailored anti-platelet therapy exist. Monitoring anti-platelet therapy ex vivo underlies several confounding parameters causing that ex vivo platelet aggregation might not reflect in vivo platelet inhibition. Methods In a single centre observational study, multiple electrode aggregometry was performed in whole blood of patients after recent coronary stent-implantation. Relative ADP-induced aggregation (r-ADP-agg) was defined as the ratio of ADP-to TRAP-induced aggregation reflecting the individual degree of P2Y(12)-mediated platelet reactivity. Results Platelet aggregation was assessed in 359 patients. Means (+/- SD) of TRAP-, ADP-induced aggregation and r-ADP-agg were 794 +/- 239 AU* min, 297 +/- 153 AU* min and 37 +/- 14%, respectively. While ADP-and TRAP-induced platelet aggregation correlated significantly with platelet count (ADP: r = 0.302;p< 0.001;TRAP: r = 0.509 p< 0.001), r-ADP-agg values did not (r = -0.003;p = 0.960). These findings were unaltered in multivariate analyses adjusting for a range of factors potentially influencing platelet aggregation. The presence of an acute coronary syndrome and body weight were found to correlate with both ADP-induced platelet aggregation and r-ADP-agg. Conclusion The ratio of ADP-to TRAP-induced platelet aggregation quantifies P2Y(12)-dependent platelet inhibition independently of the platelet count in contrast to conventional ADP-induced aggregation. Furthermore, r-ADP-agg was associated with the presence of an acute coronary syndrome and body weight as well as ADP-induced aggregation. Thus, the r-ADP-agg is a more valid reflecting platelet aggregation and potentially prognosis after coronary stent-implantation in P2Y(12)-mediated HPR than conventional ADP-induced platelet aggregation.

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