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Tytuł pozycji:

Humoral immune response to adenovirus induce tolerogenic bystander dendritic cells that promote generation of regulatory T cells.

Tytuł :
Humoral immune response to adenovirus induce tolerogenic bystander dendritic cells that promote generation of regulatory T cells.
Autorzy :
Moyer, Crystal
Kremer, Eric J.
Tran, Thi Thu Phuong
Eichholz, Karsten
Amelio, Patrizia
Nemerow, Glen R.
Perreau, Matthieu
Mennechet, Franck J. D.
Pokaż więcej
Temat :
RC581-607
Research Article
Eukaryota
Regulatory T cells
Immunologic diseases. Allergy
Spectrophotometry
Molecular Development
White Blood Cells
Immune Response
Immune System
Spectrum Analysis Techniques
Cytokines
Flow Cytometry
Animals
Immunology
Cellular Types
Monocytes
viruses
Biology and Life Sciences
RNA
Immune Physiology
Developmental Biology
Research and Analysis Methods
Blood Cells
Physiology
Immune Cells
Animal Cells
Nucleic acids
QH301-705.5
Innate Immune System
Vertebrates
Amniotes
Adenoviridae/immunology
Adenoviridae Infections/immunology
Cell Differentiation/immunology
Dendritic Cells/immunology
Humans
Immune Evasion/immunology
Immunity, Humoral/immunology
T-Lymphocytes, Regulatory/immunology
Cell Biology
Cats
Mammals
T Cells
Messenger RNA
chemical and pharmacologic phenomena
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
Biochemistry
Organisms
Cytophotometry
Medicine and Health Sciences
Biology (General)
Źródło :
PLoS Pathogens, Vol 14, Iss 8, p e1007127 (2018)
PLoS Pathogens, Public Library of Science, 2018, 14 (8), pp.e1007127. ⟨10.1371/journal.ppat.1007127⟩
PLoS pathogens, vol. 14, no. 8, pp. e1007127
Wydawca :
Public Library of Science, 2018.
Rok publikacji :
2018
Kolekcja :
DOAJ-Articles_enriched
Serveur_academique_lausannois_enriched
DOAJ-Articles
Hyper_Article_en_Ligne_enriched
Serveur_academique_lausannois
Hyper_Article_en_Ligne
Oryginalny identyfikator :
pmc: PMC6117092
pmid: 30125309
Opis pliku :
application/pdf
Język :
English
ISSN :
1553-7374
1553-7366
DOI :
10.1371/journal.ppat.1007127
Following repeated encounters with adenoviruses most of us develop robust humoral and cellular immune responses that are thought to act together to combat ongoing and subsequent infections. Yet in spite of robust immune responses, adenoviruses establish subclinical persistent infections that can last for decades. While adenovirus persistence pose minimal risk in B-cell compromised individuals, if T-cell immunity is severely compromised reactivation of latent adenoviruses can be life threatening. This dichotomy led us to ask how anti-adenovirus antibodies influence adenovirus T-cell immunity. Using primary human blood cells, transcriptome and secretome profiling, and pharmacological, biochemical, genetic, molecular, and cell biological approaches, we initially found that healthy adults harbor adenovirus-specific regulatory T cells (Tregs). As peripherally induced Tregs are generated by tolerogenic dendritic cells (DCs), we then addressed how tolerogenic DCs could be created. Here, we demonstrate that DCs that take up immunoglobulin-complexed (IC)-adenoviruses create an environment that causes bystander DCs to become tolerogenic. These adenovirus antigen loaded tolerogenic DCs can drive naïve T cells to mature into adenovirus-specific Tregs. Our study reveals a mechanism by which an antiviral humoral responses could, counterintuitively, favor virus persistence.
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