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Tytuł pozycji:

Angiogenic activity in the sera of patients with post-kidney transplant erythrocytosis

Tytuł :
Angiogenic activity in the sera of patients with post-kidney transplant erythrocytosis
Autorzy :
Maktouf, Chokri
Yaich, Soumaya
Aloui, Sabra
Bounemra, Azza
Charfeddine, Khaled
Skhiri, Habib
Hachicha, Jamil
Pokaż więcej
Temat :
MESH: Polycythemia Vera/etiology
MESH: Polycythemia Vera/blood
MESH: Polycythemia/blood
MESH: Humans
Medicine
MESH: Vascular Endothelial Growth Factor A/blood
MESH: Case-Control Studies
MESH: Kidney Transplantation/adverse effects
MESH: Up-Regulation
MESH: Prospective Studies
MESH: Enzyme-Linked Immunosorbent Assay
MESH: Biomarkers/blood
MESH: Polycythemia/diagnosis
MESH: Polycythemia/etiology
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Źródło :
Saudi Journal of Kidney Diseases and Transplantation
Saudi Journal of Kidney Diseases and Transplantation, Vol 25, Iss 5, Pp 1026-1029 (2014)
Saudi Journal of Kidney Diseases and Transplantation, Wolters Kluwer, 2014, 25 (5), pp.1026-1029. ⟨10.4103/1319-2442.139905⟩
Wydawca :
Wolters Kluwer Medknow Publications, 2014.
Rok publikacji :
2014
Kolekcja :
DOAJ-Articles
Hyper_Article_en_Ligne
Język :
English
ISSN :
1319-2442
02017903
DOI :
10.4103/1319-2442.139905
Numer akcesji :
edsair.dedup.wf.001..9dd63833c09b649b5f6c31c90cd5aa9c
International audience; Post-kidney transplant erythrocytosis (PTE) is one of the hematological complications in the renal transplant patients. While its pathogenesis still remains to be elucidated completely, a number of therapies are available for the management of PTE. The aim of this prospective study was to investigate whether angiogenesis may be involved in the pathogenesis of post-transplant erythrocytosis by comparing its level with those of different classes of erythrocytosis [polycythemia vera (PV), idiopathic erythrocytosis and secondary erythrocytosis]. The angiogenic activity was evaluated by the assessment of the serum vascular endothelial growth factor (VEGF) levels, as one of circulating angiogenic factor, using a standardized enzyme-linked immunosorbent assay commercial kit in 13 PTE (2 F/11 M), in 75 untreated erythrocytosis non-transplant patients and in 21 healthy subjects controls. The results indicated that VEGF was overproduced in advanced and untreated PV patients and to a lesser degree in idiopathic erythrocytosis thus confirming an increased angiogenic activity. However, there is no evidence of increased angiogenesis in PTE and in secondary erythrocytosis. The absence of angiogenesis in PTE and its presence in PV is another argument that the pathogenesis of these two entities is different.

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