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Tytuł pozycji:

Good local tumor control but lethal hemorrhage after apatinib treatment for intractable squamous carcinoma of the floor of the mouth: a case report

Tytuł :
Good local tumor control but lethal hemorrhage after apatinib treatment for intractable squamous carcinoma of the floor of the mouth: a case report
Autorzy :
Zhu,Xiaopeng
Liu,Min
Lv,Jincai
Guo,Liang
Li,Cheng
Dong,Lihua
Liu,Bailong
Pokaż więcej
Temat :
TKI
OncoTargets and Therapy
VEGFR2
apatinib
RC254-282
lethal bleeding
Case Report
recurrent
head and neck squamous cell carcinoma
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Źródło :
OncoTargets and Therapy, Vol Volume 11, Pp 8909-8913 (2018)
Wydawca :
Dove Medical Press, 2018.
Rok publikacji :
2018
Kolekcja :
DOAJ-Articles_enriched
DOAJ-Articles
Oryginalny identyfikator :
pmc: PMC6290870
pmid: 30573977
Opis pliku :
text/html
Język :
English
ISSN :
1178-6930
DOI :
10.2147/OTT.S180358
Xiaopeng Zhu,1,* Min Liu,1,* Jincai Lv,1 Liang Guo,2 Cheng Li,1 Lihua Dong,1 Bailong Liu1 1Department of Radiation Oncology, The First Hospital, Jilin University, Changchun 130021, China; 2Department of Pathology, The First Hospital, Jilin University, Changchun 130021, China *These authors contributed equally to this work Abstract: The treatment of repeatedly recurrent carcinoma of the floor of the mouth (FOM) is challenging. There is no standard strategy for such patients with poor physical condition after multiple lines of treatment. Angiogenesis is a key in tumor initiation, growth, and dissemination. Apatinib, a potent tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2 (VEGFR2), has been approved for the treatment of late-stage gastric or gastroesophageal junction adenocarcinoma that is resistant to at least two lines of chemotherapy. Its application in intractable FOM squamous carcinoma has never been described before. Herein, we present the case of a heavily treated patient with FOM squamous carcinoma undergoing a third local relapse in the right region of the neck and anterior cervical region. Oral apatinib was administered daily at a dose of 250 mg. There was clear and rapid efficacy that led to complete remission. However, giant, deep ulcers formed due to tumor necrosis. The patient eventually died of massive bleeding resulting from the major cervical vascular rupture caused by tumor necrosis and erosion. This case is novel and instructional, highlighting that apatinib might be effective, with manageable toxicity, for certain patients with refractory head and neck squamous cell carcinoma (HNSCC). The advantages and disadvantages of apatinib should be carefully evaluated, and close surveillance and quick intervention as required are critical to reduce fatal cancer-associated complications. The role of apatinib in recurrent or metastatic HNSCC needs to be clarified by multicenter trials in the near future. Keywords: apatinib, head and neck squamous cell carcinoma, recurrent, lethal bleeding, VEGFR2, TKI
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