Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

A Novel Scale Linking Potency and Dosage to Estimate Anticholinergic Exposure in Older Adults: the Muscarinic Acetylcholinergic Receptor ANTagonist Exposure Scale

Tytuł :
A Novel Scale Linking Potency and Dosage to Estimate Anticholinergic Exposure in Older Adults: the Muscarinic Acetylcholinergic Receptor ANTagonist Exposure Scale
Autorzy :
Klamer, Therese T.
Wauters, Maarten
Azermai, Majda
Duran, Carlos
Christiaens, Thierry
Elseviers, Monique M.
Vander Stichele, Robert
Pokaż więcej
Temat :
Medicine and Health Sciences
Pharmacology. Therapy
Źródło :
Basic and clinical pharmacology and toxicology
Basic and Clinical Pharmacology and Toxicology
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Wydawca :
Wiley-Blackwell, 2016.
Rok publikacji :
2016
Kolekcja :
Ghent_University_Academic_Bibliography
Institutional_Repository_Universiteit_Antwerpen
Ghent_University_Academic_Bibliography_enriched
Institutional_Repository_Universiteit_Antwerpen_enriched
Opis pliku :
pdf; application/pdf
ISSN :
1742-7835
DOI :
10.1111/bcpt.12699
Numer akcesji :
edsair.dedup.wf.001..a399daba4181132456924dc7fb781771
Background : Quantification of the anticholinergic exposure insufficiently or imprecisely incorporates dosage information, leading to inaccurate estimations. Aim: To construct a novel scale, including potency and dosage for the quantification of the anticholinergic exposure in older adults. Methods: Potency information was retrieved from a previous systematic review. The dosage range for each drug was delineated in minimal, maintenance, and maximal dosage for adults and older adults. Dosage information was collected from authorative sources and reviewed in an expert panel. The Muscarinic Acetylcholinergic Receptor ANTagonist Exposure (MARANTE) scale was tested for clinimetric properties using cohorts of community-dwelling older adults and nursing home residents. Results: After 3 data collection rounds, data for the dosage ranges remained incomplete for 32 active substances. Remaining gaps were filled in, and 11 dosage adjustments were proposed during the expert panel meeting. We chose the values {0; 1; 2) for the categories of potency and {0; 0.5; 1; 1.5; 2) for the levels of dosage ranges, showing good clinimetric properties. Forty-one anticholinergic drugs were prescribed in the two cohorts. Most (61%) were low potency anticholinergics, used for depression (19%, e.g. citalopram). There were 31.8% (median MARANTE 1.5, IQR 1.5 – 2.5) and 37.6% (median 2, IQR 1.5 – 2.5) anticholinergic users in the community-dwelling cohort and nursing home cohort respectively. Conclusion : The MARANTE scale combines potency with the dosage spectrum, to quantify the anticholinergic exposure in older adults. An open feedback systems on the list of anticholinergic and proposed anticholinergic potency and dosage values is advised.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies