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Title of the item:

Can Nrf2 Modulate the Development of Intestinal Fibrosis and Cancer in Inflammatory Bowel Disease?

Title :
Can Nrf2 Modulate the Development of Intestinal Fibrosis and Cancer in Inflammatory Bowel Disease?
Authors :
Pompili, Simona
Sferra, Roberta
Gaudio, Eugenio
Viscido, Angelo
Frieri, Giuseppe
Vetuschi, Antonella
Latella, Giovanni
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Subject Terms :
Chemistry
respiratory system
digestive system
colorectal cancer
Nrf2
QD1-999
IBD
inflammatory bowel disease
QH301-705.5
Review
fibrosis
cancer
intestinal fibrosis
environment and public health
Biology (General)
Source :
International Journal of Molecular Sciences, Vol 20, Iss 16, p 4061 (2019)
International Journal of Molecular Sciences
Publisher :
MDPI AG, 2019.
Publication Year :
2019
Collection :
DOAJ-Articles_enriched
DOAJ-Articles
Original Identifier :
pmc: PMC6720292
pmid: 31434263
Language :
English
ISSN :
1422-0067
DOI :
10.3390/ijms20164061
One of the main mechanisms carried out by the cells to counteract several forms of stress is the activation of the nuclear factor erythroid 2-related factor (Nrf2) signaling. Nrf2 signaling controls the expression of many genes through the binding of a specific cis-acting element known as the antioxidant response element (ARE). Activation of Nrf2/ARE signaling can mitigate several pathologic mechanisms associated with an autoimmune response, digestive and metabolic disorders, as well as respiratory, cardiovascular, and neurodegenerative diseases. Indeed, several studies have demonstrated that Nrf2 pathway plays a key role in inflammation and in cancer development in many organs, including the intestine. Nrf2 appears to be involved in inflammatory bowel disease (IBD), an immune-mediated chronic and disabling disease, with a high risk of developing intestinal fibrotic strictures and cancer. Currently, drugs able to increase cytoprotective Nrf2 function are in clinical trials or already being used in clinical practice to reduce the progression of some degenerative conditions. The role of Nrf2 in cancer development and progression is controversial, and drugs able to inhibit abnormal levels of Nrf2 are also under investigation. The goal of this review is to analyze and discuss Nrf2-dependent signals in the initiation and progression of intestinal fibrosis and cancers occurring in IBD.
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