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Tytuł pozycji:

Gut colonization by a novel Clostridium species is associated with the onset of epizootic rabbit enteropathy.

Tytuł :
Gut colonization by a novel Clostridium species is associated with the onset of epizootic rabbit enteropathy.
Autorzy :
Djukovic, Ana
Garcia-Garcera, Marc
Martínez-Paredes, Eugenio
Isaac, Sandrine
Artacho, Alejandro
Martínez, Jorge
Ubeda, Carles
Pokaż więcej
Temat :
Research Article
Animals
Clostridium/classification
Clostridium/physiology
Clostridium Infections/microbiology
Clostridium Infections/veterinary
Gastrointestinal Microbiome
Intestinal Diseases/microbiology
Intestines/microbiology
Longitudinal Studies
Prospective Studies
Rabbits
Clostridium
Veterinary medicine
SF600-1100
Enteropatia
hormones, hormone substitutes, and hormone antagonists
Źródło :
Veterinary Research 49(1) 123
Veterinary Research, Vol 49, Iss 1, Pp 1-14 (2018)
Veterinary Research, vol. 49, no. 1, pp. 123
Wydawca :
BMC, 2018.
Rok publikacji :
2018
Kolekcja :
DOAJ-Articles_enriched
ZENODO
Serveur_academique_lausannois_enriched
Diposit_Digital_de_Documents_de_la_UAB
ZENODO_enriched
DOAJ-Articles
Serveur_academique_lausannois
Diposit_Digital_de_Documents_de_la_UAB_enriched
Oryginalny identyfikator :
pmc: PMC6302431
pmid: 30572930
Opis pliku :
application/pdf
Język :
English
ISSN :
1297-9716
DOI :
10.1186/s13567-018-0617-8
Epizootic rabbit enteropathy (ERE) represents one of the most devastating diseases affecting rabbit farms. Previous studies showing transmissibility of disease symptoms through oral inoculation of intestinal contents from sick animals suggested a bacterial infectious origin for ERE. However, no etiological agent has been identified yet. On the other hand, ERE is associated with major changes in intestinal microbial communities, pinpointing dysbiosis as an alternative cause for the disease. To better understand the role of intestinal bacteria in ERE development, we have performed a prospective longitudinal study in which intestinal samples collected from the same animals before, during and after disease onset were analyzed using high-throughput sequencing. Changes in hundreds of bacterial groups were detected after the initiation of ERE. In contrast, before ERE onset, the microbiota from rabbits that developed ERE did not differ from those that remained healthy. Notably, an expansion of a single novel Clostridium species (Clostridium cuniculi) was detected the day of ERE onset. C. cuniculi encodes several putative toxins and it is phylogenetically related to the two well-characterized pathogens C. botulinum and C. perfringens. Our results are consistent with a bacterial infectious origin of ERE and discard dysbiosis as the initial trigger of the disease. Although experimental validation is required, results derived from sequencing analysis, propose a key role of C. cuniculi in ERE initiation. Electronic supplementary material The online version of this article (10.1186/s13567-018-0617-8) contains supplementary material, which is available to authorized users.

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