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Tytuł pozycji:

Risk Factors for Sporadic Non-Pregnancy Associated Listeriosis in Germany — Immunocompromised Patients and Frequently Consumed Ready-To-Eat Products

Tytuł :
Risk Factors for Sporadic Non-Pregnancy Associated Listeriosis in Germany — Immunocompromised Patients and Frequently Consumed Ready-To-Eat Products
Autorzy :
Preußel, Karina
Milde-Busch, Astrid
Schmich, Patrick
Wetzstein, Matthias
Stark, Klaus
Werber, Dirk
Pokaż więcej
Temat :
Listeriosis/pathology
Risk Factors
Listeriosis/microbiology
Germany
Pregnancy
Aged
Middle Aged
Listeriosis/etiology
610 Medizin
Listeria monocytogenes/pathogenicity
Fast Foods/adverse effects
Fast Foods/microbiology
Female
ddc:610
Humans
Male
Immunocompromised Host
Wydawca :
Robert Koch-Institut, Infektionsepidemiologie, 2015.
Rok publikacji :
2015
Kolekcja :
Publikationsserver_des_Robert_Koch-Instituts_enriched
Datacite
Datacite_enriched
Publikationsserver_des_Robert_Koch-Instituts
Opis pliku :
application/pdf
Język :
English
DOI :
10.25646/2141
Numer akcesji :
edsair.dedup.wf.001..f47cb9aa6e204b7080ed797ad1fc5695
Non-pregnancy associated (N-PA) listeriosis, caused by Listeria monocytogenes, is a rare but severe disease, and is predominantly food-borne. Most cases appear sporadic and their infection vehicle remains unknown. Incidence has increased since 2008 in Germany. We aimed to identify underlying conditions and foods associated with sporadic N-PA listeriosis in Germany. We performed a nationwide case-control study from March 2012-December 2013. Cases were sporadic N-PA listeriosis patients notified to public health. Control subjects were age (40–65 years, 66–75 years, ≥76 years) frequency-matched persons from a nationwide random telephone sample. A structured questionnaire collected information on underlying diseases, therapies and >60 food items. We conducted multivariable logistic regression analysis, adjusting for host factors identified by causal diagram theory, and calculated population attributable fractions. We enrolled 109 cases and 1982 controls. Cases’ median age was 69 years, 55% were male, 44% received immunosuppressive therapy within 3 months prior to illness onset; a further 28% had at least one immunocompromising disease. In multivariable analysis, immunosuppressive therapy (OR 8.8, 95%CI 4.9–15.6), immunocompromising disease (OR 2.7; 95%CI 1.4–5.2), gastric acid suppression (OR 3.0; 95%CI 1.4–6.3), the consumption of cold cooked sausages (OR 2.6; 95%CI 1.6–4.4), the preferred consumption of packaged cheese (OR 2.1; 95%CI 1.3–3.5) and pre-sliced cheese (OR 2.2; 95%CI 1.3–3.7) were significantly associated with N-PA listeriosis. These foods accounted for 59% of all cases. Typical high risk foods, e.g. cold seafood, certain types of cheeses, tended to be negatively associated with disease. In conclusion, immunosuppressive therapy and frequently consumed ready-to-eat foods are the main risk factors for sporadic N-PA listeriosis in Germany. To reduce their risk, immunocompromised persons should consume the identified foods well before the ‘use-by’ date. The microbiological criteria for Listeria monocytogenes in ready-to-eat foods may insufficiently protect persons who are markedly immunocompromised.

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