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Tytuł pozycji:

Manipulation of Ovarian Function Significantly Influenced Sarcopenia in Postreproductive-Age Mice

Tytuł :
Manipulation of Ovarian Function Significantly Influenced Sarcopenia in Postreproductive-Age Mice
Autorzy :
Peterson, Rhett L.
Parkinson, Kate C.
Mason, Jeffrey B.
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Temat :
Article Subject
lcsh:Surgery
lcsh:RD1-811
Lean body mass
Internal medicine
medicine.medical_specialty
medicine
Transplantation
business.industry
business
Body water
Fat mass
Health span
Endocrinology
Body weight
Sarcopenia
medicine.disease
Ovarian function
Research Article
Źródło :
Journal of Transplantation, Vol 2016 (2016)
Journal of Transplantation
Wydawca :
Hindawi Publishing Corporation, 2016.
Rok publikacji :
2016
Opis pliku :
text/xhtml
Język :
English
ISSN :
2090-0007
DOI :
10.1155/2016/4570842
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331ff07189e2bb3dedc25297075b6c05
Prawa :
OPEN
Numer akcesji :
edsair.doi.dedup.....331ff07189e2bb3dedc25297075b6c05
Previously, transplantation of ovaries from young cycling mice into old postreproductive-age mice increased life span. We anticipated that the same factors that increased life span could also influence health span. Female CBA/J mice received new (60 d) ovaries at 12 and 17 months of age and were evaluated at 16 and 25 months of age, respectively. There were no significant differences in body weight among any age or treatment group. The percentage of fat mass was significantly increased at 13 and 16 months of age but was reduced by ovarian transplantation in 16-month-old mice. The percentages of lean body mass and total body water were significantly reduced in 13-month-old control mice but were restored in 16- and 25-month-old recipient mice by ovarian transplantation to the levels found in six-month-old control mice. In summary, we have shown that skeletal muscle mass, which is negatively influenced by aging, can be positively influenced or restored by reestablishment of active ovarian function in aged female mice. These findings provide strong incentive for further investigation of the positive influence of young ovaries on restoration of health in postreproductive females.

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